Results 61 to 70 of about 38,975 (250)
Hedgehog Signaling and Steroidogenesis [PDF]
Annual Review of Physiology, 2015 Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta.
Isabella, Finco +3 more
openaire +2 more sources
Cells, 2022 Adrenocortical carcinoma is a heterogeneous and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. In this study, we have assessed for the preclinical gold standard NCI-H295 in direct comparison with the more recently ...
Sandra Sigala +9 more
doaj +1 more source
Neuroprotection, EarlyView.Abstract Aim Aromatase is the key enzyme in the biosynthesis of 17β‐estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variants increase susceptibility to stroke. This study aims to determine whether aromatase overexpression improves stroke outcome and
Lindsay Gallagher +8 more
wiley +1 more source
Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
Frontiers in Endocrinology, 2023 Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free ...
Tarique Hussain +12 more
doaj +1 more source
Pediatric Discovery, EarlyView.Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang +7 more
wiley +1 more source
Optic Atrophy 1- Dependent Mitochondrial Remodeling Controls Steroidogenesis in Trophoblasts
, 2012 During human pregnancy, placental trophoblasts differentiate and syncytialize into syncytiotrophoblasts that sustain progesterone production [1]. This process is accompanied by mitochondrial fragmentation and cristae remodeling [2], two facets of ...
Rafelski, S. M. +2 more
core +2 more sources
Environmental Toxicology, EarlyView.ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos +3 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó +9 more
wiley +1 more source
Chemical Structure and Effects in a High-Throughput Steroidogenesis Assay
, 2022 Datasets for "Chemical Structure and Effects in a High-Throughput Steroidogenesis Assay" for ORD-047844.
Grace Patlewicz (1845178) +1 more
core +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Acetamiprid (ACP) is a neonicotinoid pesticide that is extensively utilized for the management of insect populations, but its toxic effects on the male reproductive system have become a source of concern. Chrysin (CHR) is a natural flavone found in many plants and bee products, including honey and propolis.
Selim Demir +7 more
wiley +1 more source