Results 51 to 60 of about 38,975 (250)

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Adaptive and Biological Responses of Buffalo Granulosa Cells Exposed to Heat Stress under In Vitro Condition

Animals, 2021
The steroidogenesis capacity and adaptive response of follicular granulosa cells (GCs) to heat stress were assessed together with the underlying regulating molecular mechanisms in Egyptian buffalo.
Marwa S. Faheem, Nasser Ghanem, Ahmed Gad, Radek Procházka, Sherif M. Dessouki   +4 more
doaj   +1 more source

P450 oxidoreductase deficiency: a new disorder of steroidogenesis

, 2005
Microsomal P450 enzymes, which metabolize drugs and catalyze steroid biosynthesis require electron donation from NADPH via P450 oxidoreductase (POR). POR knockout mice are embryonically lethal, but we found recessive human POR missense mutations causing ...
Flück, Christa E., Agrawal, Vishal, Miller, Walter L., VISHAL AGRAWAL, Huang, Ningwu, AMIT V. PANDEY, NINGWU HUANG, WALTER L. MILLER, Pandey, Amit Vikram, CHRISTA E. FLÜCK   +9 more
core   +1 more source

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

Therapeutic implications of brain steroidogenesis

, 2017
The nervous system is a steroidogenic tissue and several steroids synthesized locally in the brain, such as pregnenolone, progesterone and estradiol, modulate neuronal and glial physiology and are neuroprotective. The brain upregulates steroidogenesis at
Azcoitia, I., García-Segura, Luis M., Doncarlos, Lydia L., Arévalo, María Ángeles   +3 more
core   +1 more source

Interlinkage between inflammation, oxidative stress, and endoplasmic reticulum stress in bisphenols-induced testicular steroidogenesis disturbance: A mini review

International Journal of Reproductive BioMedicine
Bisphenols (BP) are endocrine-disrupting chemicals that cause adverse health effects, including testicular steroidogenesis disturbance. Cyclo-oxygenase-2 and nuclear factor erythroid 2-related factor 2 are the target molecules involved in testicular ...
Nur Erysha Sabrina Jefferi, Asma Afifah Shamhari, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib   +4 more
doaj   +1 more source

Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts

, 2022
Placentation and placental steroidogenesis are important for pregnancy and maternal–fetal health. As pregnancy progresses, the main site of progesterone (P4) synthesis changes from the corpus luteum to the placenta, in which placental trophoblasts ...
Yan Liu, Xin Cao, Liu, Yan, Ding, Hongxiang, Yueshuai Liu, Yang, Yuze, Yuze Yang, Cao, Xin, Hongxiang Ding, Tao Feng, Liu, Yueshuai, Feng, Tao   +11 more
core   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Human Adrenocarcinoma (H295R) Cells as Potential Predictors of Bisphenols Ability to Interfere with Steroid Hormone Production: A Mini Review

Scientific Papers Animal Science and Biotechnologies, 2023
The focus on the refinement, reduction and replacement of animal use in toxicity testing requires the development of cell-based systems that mimic the effects of xenobiotics including bisphenols in human tissues.
Nikola Knížatová, Hana Greifová, Katarína Tokárová, Norbert Lukáč   +3 more
doaj  

Effects of Summer Heat Stress on Physiological Parameters and Reproductive Efficiency of Barbarine Ewes Under Natural Outdoor or Indoor Conditions

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Climate change and rising ambient temperatures increasingly challenge sheep production systems in arid and semi‐arid regions, particularly during the summer breeding season. This study evaluated the effects of heat stress and direct solar exposure on physiological responses, metabolic profile, and reproductive performance of Barbarine ewes, a ...
Samia Khnissi, Dorra Aouadi, Hela Chalouati, Mourad Rekik, Imène Ben Salem   +4 more
wiley   +1 more source