Results 51 to 60 of about 43,028 (255)

Evaluation of therapeutic effects of D‐limonene following orchiopexy in the rat model of cryptorchidism

Animal Models and Experimental Medicine, EarlyView.
D‐limonene supplementation enhances testicular recovery following orchiopexy in a rat model of bilateral cryptorchidism. Treatment with D‐limonene reduces oxidative stress (↓MDA, ↑SOD, ↑GPx, ↑TAC), downregulates pro‐apoptotic proteins (↓TNF‐α, ↓BAX, ↓Caspase‐3), and upregulates anti‐apoptotic Bcl‐2 expression.
Arman Norouzi‐Ghalehbala, Mohammadjavad Rezaei‐Varmaziar, Majid Taati, Ali Soleimanzadeh, Abbas Raisi, Farshid Davoodi, Amir Ali Shahbazfar   +6 more
wiley   +1 more source

Adaptive and Biological Responses of Buffalo Granulosa Cells Exposed to Heat Stress under In Vitro Condition

Animals, 2021
The steroidogenesis capacity and adaptive response of follicular granulosa cells (GCs) to heat stress were assessed together with the underlying regulating molecular mechanisms in Egyptian buffalo.
Marwa S. Faheem, Nasser Ghanem, Ahmed Gad, Radek Procházka, Sherif M. Dessouki   +4 more
doaj   +1 more source

IGF2 increases de novo steroidogenesis in prostate cancer cells

, 2013
Free to read\ud \ud Androgen-dependent pathways regulate maintenance and growth of normal and malignant prostate tissues. Androgen deprivation therapy (ADT) exploits this dependence and is used to treat metastatic prostate cancer; however, regression ...
Hollier, Brett G., Gleave, Martin, Fazli, Ladan, Herington, Adrian, Hendy, Stephen C., Pollak, Michael N., Lubik, Amy, Gunter, Jennifer, Ettinger, Susan, Stylianou, Nataly, Adomat, Hans, Nelson, Colleen C.   +11 more
core   +1 more source

MOESM1 of Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies [PDF]

, 2018
Additional file 1.
O'Hara, Laura, O’hara, Laura; id_orcid, Tom Freeman (3440), O’shaughnessy, Peter J., Laura O’Hara (5141273), Lee B. Smith, Peter O’Shaughnessy (4845118), Laura O’Hara, Tom C. Freeman, Freeman, TC, Smith, LB, Peter J. O’Shaughnessy, O'Shaughnessy, Peter J., Lee Smith (59284), O'Shaughnessy, PJ, Freeman, Tom C., Smith, Lee B., O'Hara, L   +17 more
core   +1 more source

Determining the timeline of gonadal and genital differentiation in male and female equine fetuses allows for early detection and intervention in malformations

The Anatomical Record, EarlyView.
Abstract Sexual differentiation in the equine fetus involves coordinated morphogenetic processes that shape both the gonads and the genital ducts. Although the formation of testes and ovaries has been relatively well documented, the temporal dynamics and morphometric patterns of the mesonephric (Wolffian) and paramesonephric (Müllerian) ducts remain ...
Tais Harumi de Castro Sasahara, Silvio Pires Gomes, Fabio Cesar Magioli Abdala, Bruno Cesar Schimming, Maria Angelica Miglino   +4 more
wiley   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

Interlinkage between inflammation, oxidative stress, and endoplasmic reticulum stress in bisphenols-induced testicular steroidogenesis disturbance: A mini review

International Journal of Reproductive BioMedicine
Bisphenols (BP) are endocrine-disrupting chemicals that cause adverse health effects, including testicular steroidogenesis disturbance. Cyclo-oxygenase-2 and nuclear factor erythroid 2-related factor 2 are the target molecules involved in testicular ...
Nur Erysha Sabrina Jefferi, Asma Afifah Shamhari, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib   +4 more
doaj   +1 more source

Human Adrenocarcinoma (H295R) Cells as Potential Predictors of Bisphenols Ability to Interfere with Steroid Hormone Production: A Mini Review

Scientific Papers Animal Science and Biotechnologies, 2023
The focus on the refinement, reduction and replacement of animal use in toxicity testing requires the development of cell-based systems that mimic the effects of xenobiotics including bisphenols in human tissues.
Nikola Knížatová, Hana Greifová, Katarína Tokárová, Norbert Lukáč   +3 more
doaj  

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma

Cells, 2022
Adrenocortical carcinoma is a heterogeneous and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. In this study, we have assessed for the preclinical gold standard NCI-H295 in direct comparison with the more recently ...
Sandra Sigala, Christina Bothou, David Penton, Andrea Abate, Mirko Peitzsch, Deborah Cosentini, Guido A. M. Tiberio, Stefan R. Bornstein, Alfredo Berruti, Constanze Hantel   +9 more
doaj   +1 more source