Results 71 to 80 of about 38,975 (250)

Assessment of Oxidative Stress, Vitellogenin, and Human Health Risks Derived From Nile Tilapia Exposed to Metals and Metalloids in Southeastern Brazil

Environmental Toxicology, EarlyView.
ABSTRACT Urban coastal lagoons are highly vulnerable ecosystems increasingly affected by metal contamination, as well as multiple anthropogenic stressors. This study evaluated ecotoxicological and human health risks associated with chronic metal exposure in Nile tilapia (Oreochromis niloticus) from an anthropogenically impacted lagoon in southeastern ...
Julia Araújo Alves, Priscila M. O. Muniz Cunha, Shênia Patrícia Corrêa Novo, Lorena Oliveira Souza Soares, Tatiana Dillenburg Saint‐Pierre, Fábio Veríssimo Correia, André Luís de Sá Salomão, Rachel Ann Hauser‐Davis, Enrico Mendes Saggioro   +8 more
wiley   +1 more source

Nutrient status alters developmental fates via a switch in mitochondrial homeodynamics

Nature Communications
Steroid hormones are powerful endocrine regulators, but little is known about how environmental conditions modulate steroidogenesis to reprogram developmental fates.
Jie Zhang, Suning Liu, Yang Li, Guanfeng Xu, Huimin Deng, Kirst King-Jones, Sheng Li   +6 more
doaj   +1 more source

Juvenile and Pubertal Exposure to Polystyrene Nanoplastics Impairs Epididymal Structure and Sperm Quality in Mice

Environmental Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are emerging environmental contaminants capable of crossing biological barriers, accumulating in tissues, and disrupting physiological pathways. The male reproductive system is particularly vulnerable during the postnatal period, a developmental window characterized by intense testicular differentiation and epididymal ...
Gabriel Magalhães Oliveira Rigo, Nicoly Caixêta Gonçalves, Cristiana Livramento Oliveira Pinto, Patrícia Corona Lopes, Raul Silva Santarem, Juliana Reis Machado, Régia Caroline Peixoto Lira, Ana Paula Ramos, Marcos Vinicius da Silva, Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo   +10 more
wiley   +1 more source

Drp1 Phosphorylation Is Indispensable for Steroidogenesis in Leydig Cells

, 2019
The initial steps of steroidogenesis occur in the mitochondria. Dynamic changes in the mitochondria are associated with their fission and fusion. Therefore, understanding the cellular and molecular relationships between steroidogenesis and mitochondrial ...
Kim, YJ, Jeong, SY, Park, HT, Park, JE, Lee, SG, Kim, JM, Kim, JY, Yun, J, Koh, H, Yoo, YH, Chung, JY   +10 more
core   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Garlic Alleviates the Injurious Impact of Cyclosporine-A in Male Rats through Modulation of Fibrogenic and Steroidogenic Genes

Animals, 2020
This work aimed to study the hepato-testicular protective effect of garlic in rats treated with cyclosporine A (CsA). Forty male Westar albino rats were randomly distributed in five groups (8 rats each): control, olive oil, garlic, CsA, and CsA co ...
Mustafa Shukry, Saqer S. Alotaibi, Sarah M. Albogami, Nora Fathallah, Foad Farrag, Mahmoud A. O. Dawood, Mahmoud S. Gewaily   +6 more
doaj   +1 more source

Cortisol synthesis by primary human keratinocytes

, 2009
PhDCortisol analogues have been used to treat skin disorders, such as psoriasis and atopic dermatitis, for over 50 years but the ability of normal human keratinocytes to synthesise cortisol has not been reported.
Hannen, Rosalind Francesca
core  

Establishment of a Novel Human Fetal Adrenal Culture Model that Supports de Novo and Manipulated Steroidogenesis [PDF]

, 2020
Context: Disorders affecting adrenal steroidogenesis promote an imbalance in the normally tightly controlled secretion of mineralocorticoids, glucocorticoids, and androgens.
Hare, Kristine Juul, Thuesen, Lea Langhoff, Lundvall, Lene, Langhoff Thuesen, Lea, Nielsen, John E., Hammerum, Mette Schou, Mitchell, Rod T, Mitchell, Rod T., Perlman, Signe, Jørgensen, Anne, Juul, Anders, Schou Hammerum, Mette, Melau, Cecilie, Juul Hare, Kristine, Frederiksen, Hanne, Nielsen, John E   +15 more
core   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis

, 2012
[[abstract]]We demonstrate the mechanism by which Cordyceps sinensis (CS) mycelium regulates Leydig cell steroidogenesis. Mouse Leydig cells were treated with forskolin, H89, phorbol 12-myristate 13-acetate, staurosporine, or steroidogenic enzyme ...
黃元勵;Huang, Yuan-Li
core