Results 91 to 100 of about 43,028 (255)

Intratesticular Control Of Steroidogenesis [PDF]

Clinical Endocrinology, 1990
Men are men because of testosterone, and the effects of this hormone are evident in virtually every organ or tissue in a normal adult man. Because testosterone is a classical endocrine hormone with effects throughout the body, many endocrinologists will have failed to realize that, in terms of its effects on fertility, the primary role of testosterone ...
openaire   +2 more sources

Prevalence of HCMV, HHV‐6, and HSV‐1/2 in the semen of men attending infertility clinics and their association with semen parameters

UroPrecision, EarlyView.
Abstract Background Viral infections have been identified as potential disruptors of male reproductive health. This study aimed to investigate the prevalence of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV‐6), and herpes simplex virus types 1 and 2 (HSV‐1/2) DNA in semen samples from fertile and infertile men within the potential impact of ...
Seyedeh Zahra Hashemi, Neda Pirbonyeh, Fahime Edalat, Narges Eslami, Saeed Tajik, Arash Letafati, Jamal Sarvari, Afagh Moattari   +7 more
wiley   +1 more source

Molecular profiling of signaling pathways involved in chicken ovarian follicle development by transcriptome sequencing

Frontiers in Veterinary Science
Ovarian follicle development in chickens is a dynamic and closely controlled biological process crucial to avian reproduction. Each stage of folliculogenesis is characterized by distinct morphological and molecular alterations, regulated by complex ...
Armughan Ahmed Wadood, Armughan Ahmed Wadood, Farhad Bordbar, Farhad Bordbar, Muhammad Safdar, Xiquan Zhang, Xiquan Zhang   +6 more
doaj   +1 more source

Drp1 Phosphorylation Is Indispensable for Steroidogenesis in Leydig Cells

, 2019
The initial steps of steroidogenesis occur in the mitochondria. Dynamic changes in the mitochondria are associated with their fission and fusion. Therefore, understanding the cellular and molecular relationships between steroidogenesis and mitochondrial ...
Kim, YJ, Jeong, SY, Park, HT, Park, JE, Lee, SG, Kim, JM, Kim, JY, Yun, J, Koh, H, Yoo, YH, Chung, JY   +10 more
core   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Modulation of bone morphogenetic protein activity by melatonin in ovarian steroidogenesis

Reproductive Medicine and Biology, 2018
Background Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a
Fumio Otsuka
doaj   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Identification of Novel Regulators of Adrenal Steroidogenesis [PDF]

Steroid hormones are indispensable signaling molecules for organismal homeostasis. Steroid synthesis is known to be regulated by control of the supply of cholesterol to mitochondria where the first steroid in the pathway, pregnenolone, is produced.
Melchinger, Philipp Ferdinand
core  

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Development and Clinical Significance of the Human Fetal Adrenal Gland as a Key Component of the Feto-Placental System: A Systematic Review

Reproductive Medicine
Background: The human fetal adrenal gland is a unique endocrine organ with distinct morphology and functional dynamics, which is significantly different from the postnatal adrenal.
Martiniuc Ana-Elena, Laurentiu-Camil Bohiltea, Pop Lucian Gheorghe, Suciu Nicolae   +3 more
doaj   +1 more source