Results 191 to 200 of about 59,068 (232)
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Danazol Inhibits Steroidogenesis
Fertility and Sterility, 1977Danazol was found to inhibit multiple enzymes of steroidogenesis directly in the pregnant mare serum (PMS)-treated hamster ovary and the rat testis and adrenal in vitro. In the PMS-treated hamster ovary, danazol inhibited 17alpha-hydroxylase, 17,20-lyase, and 3beta-hydroxysteroid dehydrogenase.
R L, Barbieri +5 more
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Molecular and Cellular Endocrinology, 2004
Cytokines interfere with steroidogenesis at the level of the adrenals, testes, and ovaries. Within the adrenal, macrophages, and lymphocytes, physiologically widely infiltrating the adrenal cortex, and adrenocortical, and chromaffin cells produce cytokines, as IL-1, IL-6, TNFalpha, leukemia inhibitory factor (LIF), and IL-18 which have a key role in ...
S R, Bornstein, H, Rutkowski, I, Vrezas
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Cytokines interfere with steroidogenesis at the level of the adrenals, testes, and ovaries. Within the adrenal, macrophages, and lymphocytes, physiologically widely infiltrating the adrenal cortex, and adrenocortical, and chromaffin cells produce cytokines, as IL-1, IL-6, TNFalpha, leukemia inhibitory factor (LIF), and IL-18 which have a key role in ...
S R, Bornstein, H, Rutkowski, I, Vrezas
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Gossypol inhibits testicular steroidogenesis
Fertility and Sterility, 1981Gossypol, a compound isolated from cottonseed, has been used in the People's Republic of China as an antifertility agent in men. It was reported that gossypol is highly effective in reducing sperm count. Our study suggests that gossypol inhibits luteinizing hormone, 8-bromo-adenosine 3',5'-monophosphate-induced testosterone formation, and the ...
Lin, T. U. +4 more
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Steroidogenesis in testicular cells
Journal of Steroid Biochemistry, 1979Abstract The current state of knowledge concerning steroid biosynthesis and metabolism in isolated testicular cells is discussed. Data demonstrating conversion of progesterone to testosterone and 5α-reduced androgens in cultures of pure Sertoli cells derived from adult rat testes is presented.
E, Steinberger +2 more
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Transient intermediates in steroidogenesis
Journal of Steroid Biochemistry, 1975Abstract Analogs of cholesterol and pregnenolone have been synthesized and tested as hormonal precursors. Homologues of cholesterol in which C-22 is completely substituted (e.g. (20R-20-t-butyl)-5-pregnene-3)β,20 diol, (20R)-20-(phenyl)-5-pregnene-3β,20 diol) were incubated with acetone powders of adrenal glands and appropriate cofactors and each was
R B, Hochberg +3 more
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2017
Testosterone is the major androgen in circulation in male humans produced primarily in the Leydig cells of the testis. Biosynthesis of testosterone from cholesterol occurs via a series of enzymatic reactions. Testosterone may be further metabolized into a more potent androgen dihydrotestosterone.
Christa E. Flück, Amit V. Pandey
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Testosterone is the major androgen in circulation in male humans produced primarily in the Leydig cells of the testis. Biosynthesis of testosterone from cholesterol occurs via a series of enzymatic reactions. Testosterone may be further metabolized into a more potent androgen dihydrotestosterone.
Christa E. Flück, Amit V. Pandey
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Steroidogenesis: Unanswered Questions
Yearbook of Paediatric Endocrinology, 2017Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid structures and measuring steroid concentrations in body fluids. The molecular biology revolution radically revolutionized studies of steroidogenesis with the cloning of known steroidogenic enzymes, by identifying novel factors, and delineating the genetic basis of ...
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Disorders of Adrenal Steroidogenesis
Pediatric Clinics of North America, 1987This article reviews the processes of normal adrenal function, including the three main classes of hormones. From there it describes reduced or absent enzyme activity in the stages of steroid synthesis, and proceeds to outline the enzyme deficiency responsible for the clinical effects that manifest themselves in characteristic metabolic disturbances.
S, Drucker, M I, New
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Gene regulation of steroidogenesis
The Journal of Steroid Biochemistry and Molecular Biology, 1995The biosynthesis of various steroid hormones in animal tissues are catalyzed by six forms of cytochrome P450 and two hydroxysteroid dehydrogenases. The tissue-specific expression of these enzymes, which are under the control of the pituitary gland and mainly regulated at the transcriptional level, determines the steroidogenesis of animal tissues ...
T, Omura, K, Morohashi
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