Results 201 to 210 of about 43,028 (255)

Transient intermediates in steroidogenesis

Journal of Steroid Biochemistry, 1975
Abstract Analogs of cholesterol and pregnenolone have been synthesized and tested as hormonal precursors. Homologues of cholesterol in which C-22 is completely substituted (e.g. (20R-20-t-butyl)-5-pregnene-3)β,20 diol, (20R)-20-(phenyl)-5-pregnene-3β,20 diol) were incubated with acetone powders of adrenal glands and appropriate cofactors and each was
R B, Hochberg, P D, McDonald, S, Ladany, S, Lieberman   +3 more
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Steroidogenesis in testicular cells

Journal of Steroid Biochemistry, 1979
Abstract The current state of knowledge concerning steroid biosynthesis and metabolism in isolated testicular cells is discussed. Data demonstrating conversion of progesterone to testosterone and 5α-reduced androgens in cultures of pure Sertoli cells derived from adult rat testes is presented.
E, Steinberger, R K, Tcholakian, A, Steinberger   +2 more
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Testicular Steroidogenesis

2017
Testosterone is the major androgen in circulation in male humans produced primarily in the Leydig cells of the testis. Biosynthesis of testosterone from cholesterol occurs via a series of enzymatic reactions. Testosterone may be further metabolized into a more potent androgen dihydrotestosterone.
Christa E. Flück, Amit V. Pandey
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The development of steroidogenesis

The American Journal of Medicine, 1972
Abstract Early in human development steroid-producing cells appear; the first of these are the trophoblastic cells of the placenta. Although active in the production of progesterone and estrogens, the syncytiotrophoblast lacks several key enzymes in steroid metabolism and therefore the placenta is an incomplete steroidogenic tissue.
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Benzodiazepines and steroidogenesis

Journal of Endocrinology, 1992
Abstract Over the last 3 years, two rather disparate areas of biological research have come together unexpectedly, and the information that is emerging may not only fill in some of the gaps in our knowledge of the mechanism of stimulation of steroidogenesis, but also gives new insights into potential interactions between the nervous ...
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Danazol Inhibits Steroidogenesis

Fertility and Sterility, 1977
Danazol was found to inhibit multiple enzymes of steroidogenesis directly in the pregnant mare serum (PMS)-treated hamster ovary and the rat testis and adrenal in vitro. In the PMS-treated hamster ovary, danazol inhibited 17alpha-hydroxylase, 17,20-lyase, and 3beta-hydroxysteroid dehydrogenase.
R L, Barbieri, J A, Canick, A, Makris, R B, Todd, I J, Davies, K J, Ryan   +5 more
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Role of mitochondria in steroidogenesis

Best Practice & Research Clinical Endocrinology & Metabolism, 2012
Adrenal gonadal, placental and brain mitochondria contain several steroidogenic enzymes, notably the cholesterol side chain cleavage enzyme, P450scc, which is the enzymatic rate-limiting step in steroidogenesis which determines cellular steroidogenic capacity.
Vassilios, Papadopoulos, Walter L, Miller   +1 more
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Gene regulation of steroidogenesis

The Journal of Steroid Biochemistry and Molecular Biology, 1995
The biosynthesis of various steroid hormones in animal tissues are catalyzed by six forms of cytochrome P450 and two hydroxysteroid dehydrogenases. The tissue-specific expression of these enzymes, which are under the control of the pituitary gland and mainly regulated at the transcriptional level, determines the steroidogenesis of animal tissues ...
T, Omura, K, Morohashi
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Inhibition of Steroidogenesis by Cyanoketone

Gynecologic and Obstetric Investigation, 2010
The effect of cyanoketone on some steps of steroidogenesis has been studied on testicular and adrenal tissue of male Wistar rats. Pregnenolone, dehydroepiandrosterone and progesterone (4-C14) have been used as substrates. The metabolites have been separated by thin layer chromatography and identified by crystallization to constant specific activity ...
C L, Di Prisco, G, Materazzi, B, Scattolini   +2 more
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REGULATION OF STEROIDOGENESIS IN TESTIS

Journal of Steroid Biochemistry, 1974
Abstract The endogenous neutral steroids in human, boar and rat testis tissue were investigated by gas-liquid chromatography and gas chromatography-mass spectrometry. In addition, the secretion of these steroids by human testis was investigated under basal conditions as well as during human chorionic gonadotrophin (HCG) administration. In man and rat
R. Vihko, A. Ruokonen
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