Results 1 to 10 of about 9,122 (180)

Syntheses and medicinal chemistry of spiro heterocyclic steroids [PDF]

Beilstein Journal of Organic Chemistry
There is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis of such hybrids among research groups. In this review, we present
Laura L. Romero-Hernández, Ana Isabel Ahuja-Casarín, Penélope Merino-Montiel, Sara Montiel-Smith, José Luis Vega-Báez, Jesús Sandoval-Ramírez   +5 more
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Molecular Cloning, Heterologous Expression, Purification, and Evaluation of Protein–Ligand Interactions of CYP51 of Candida krusei Azole-Resistant Fungal Strain

Biomedicines, 2023
Due to the increasing prevalence of fungal diseases caused by fungi of the genus Candida and the development of pathogen resistance to available drugs, the need to find new effective antifungal agents has increased.
Tatsiana V. Tsybruk, Leonid A. Kaluzhskiy, Yuri V. Mezentsev, Tatyana N. Makarieva, Kseniya M. Tabakmaher, Natalia V. Ivanchina, Pavel S. Dmitrenok, Alexander V. Baranovsky, Andrei A. Gilep, Alexis S. Ivanov   +9 more
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Highlights on Steroidal Arylidene Derivatives as a Source of Pharmacologically Active Compounds: A Review

Molecules, 2021
Steroids constitute a unique class of chemical compounds, playing an important role in physiopathological processes, and have high pharmacological interest.
Vanessa Brito, Gilberto Alves, Paulo Almeida, Samuel Silvestre   +3 more
doaj   +1 more source

Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

Chemistry Proceedings, 2023
Heterocyclic derivatives of hormones have attracted great interest as a privileged scaffold for drug discovery due to their outstanding biological activity.
Yulia Volkova, Alexander Scherbakov, Igor Zavarzin   +2 more
doaj   +1 more source

Evaluating the functional, sexual and seasonal variation in the chemical constituents from feces of adult Iberian wolves (Canis lupus signatus)

Scientific Reports, 2023
Chemical signals deposited in feces play an important role in intraspecific and interspecific communication of many mammals. We collected fresh feces of adult wolves from wild breeding groups.
Isabel Barja, Ana Piñeiro, Aritz Ruiz-González, Amaia Caro, Pilar López, José Martín   +5 more
doaj   +1 more source

Promising Perspectives of the Antiproliferative GPER Inverse Agonist ERα17p in Breast Cancer

Cells, 2023
The estrogen receptor α (ERα) corresponds to a large platform in charge of the recruitment of a panel of molecules, including steroids and related heterocyclic derivatives, oligonucleotides, peptides and proteins.
Marilena Kampa, Rosamaria Lappano, Fedora Grande, Bruno Rizzuti, Marcello Maggiolini, Elias Castanas, Yves Jacquot   +6 more
doaj   +1 more source

Synthesis of Thiophenyl, Thiazolyl, and Pyridinyl Androstane Derivatives: A Novel Class of Potent Anti-inflammatory and Anti-ulcerogenic Heterocyclic Steroids [PDF]

Journal of Bioscience and Applied Research, 2019
The investigation of drugs used for the treatment of inflammatory diseases with limited side effects becomes an urgent need for inflammation patients.
Mervat Abd-Elhalim, Maher Helal, Dina El-kady, Nahed Kamel, Amany Sleem, Omar Abdel-Salam, Amira Abdallah, Gamal Elmegeed   +7 more
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Chemical Constitution and Antimicrobial Activity of Kefir Fermented Beverage

Molecules, 2021
Kefir beverage (KB) is a fermented milk initiated by kefir grains rich with starter probiotics. The KB produced in this study seemed to contain many chemical compounds elucidated by gas chromatography–mass spectrometry (GC-MS) and IR spectra.
Abdul-Raouf Al-Mohammadi, Rehab A. Ibrahim, Ahmed H. Moustafa, Ahmed A. Ismaiel, Azza Abou Zeid, Gamal Enan   +5 more
doaj   +1 more source

Substitutional Diversity-Oriented Synthesis and In Vitro Anticancer Activity of Framework-Integrated Estradiol-Benzisoxazole Chimeras

Molecules, 2022
Hybridization of steroids and other pharmacophores often modifies the bioactivity of the parent compounds, improving selectivity and side effect profile.
Ferenc Kovács, Dóra Izabella Adamecz, Ferenc István Nagy, Benedek Papp, Mónika Kiricsi, Éva Frank   +5 more
doaj   +1 more source

Multistep Synthesis and In Vitro Anticancer Evaluation of 2-Pyrazolyl-Estradiol Derivatives, Pyrazolocoumarin-Estradiol Hybrids and Analogous Compounds

Molecules, 2020
Although the hormone independent cytotoxic activity of several estradiol derivatives endowed with a simple substituent at C-2 has been reported so far, 2-heterocyclic and 2,3-condensed analogs are less investigated from both synthetic and pharmacological
Barnabás Molnár, Mohana Krishna Gopisetty, Dóra Izabella Adamecz, Mónika Kiricsi, Éva Frank   +4 more
doaj   +1 more source