Results 31 to 40 of about 9,122 (180)

In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. [PDF]

, 2016
The long-term overall survival of Ewing sarcoma (EWS) patients remains poor; less than 30% of patients with metastatic or recurrent disease survive despite aggressive combinations of chemotherapy, radiation and surgery.
Alturkmani, Hani, Baltezor, Michael, Butte, Atul J, Chen, Bin, Flynn, Colleen A, Godwin, Andrew K, Hyter, Stephen, Ma, Yan, Neville, Kathleen A, Pessetto, Ziyan Y, Rosenthal, Howard G, Weir, Scott J   +11 more
core   +3 more sources

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Steps in immunosuppression for renal transplantation [PDF]

, 1983
The authors provide a historical survey of the immunosuppressive agents that have been used to prevent allograft rejection.
Hakala, TR, Rosenthal, JT, Starzl, TE
core  

Phytochemical Analysis of Veratrum Alkaloids in Medicinal Veratrum Globules Using High‐Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry

Biomedical Chromatography, Volume 40, Issue 3, March 2026.
ABSTRACT Veratrum L. species have been used in traditional medicine for centuries due to their bioactive properties, yet they also contain toxic steroid alkaloids that pose potential health risks when present in herbal preparations. Reliable analytical approaches are therefore essential to ensure product safety, protect consumer health and assess ...
Julia Siegle, Jörg Pietsch
wiley   +1 more source

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Silver nanoparticles biogenically synthesised using Maclurodendron porteri extract and their bioactivities

Heliyon
Silver nanoparticle is widely used in various field including medical, cosmetic, food and industrial purposes due to their unique properties in electrical conductivity, thermal, and biological activities. In the medical field, silver nanoparticles (AgNPs)
Nadhirah Badrillah, Deny Susanti, Tengku Karmila Tengku Mohd Kamil, Greesty Finotory Swandiny, Yuli Widyastuti, Erizal Zaini, Muhammad Taher   +6 more
doaj   +1 more source

Analysis of the Cramer classification scheme for oral systemic toxicity - implications for its implementation in Toxtree [PDF]

, 2011
In the application of the Threshold of Toxicological Concern (TTC) concept to non-cancer endpoints, the decision tree proposed by Cramer, Ford and Hall in 1978, commonly referred to as the Cramer scheme, is probably the most widely used approach for ...
LAPENNA SILVIA, WORTH Andrew
core   +1 more source

Linking Nutritional, Sensory, and Functional Quality in Plant‐Based Proteins Through Structural Modification and Computational Insights

Sustainable Food Proteins, Volume 4, Issue 1, March 2026.
The lacking essential amino acids, low digestibility, bioavailability, bitterness, and presence of anti‐nutritional factors that limit the consumption of plant proteins and their use in food formulations are discussed comprehensively. The findings of recent studies on novel technologies and computer‐based applications used to cope with these challenges
Humeyra Cavdar Dincturk, Rukiye Gundogan, Asli Can Karaca, Esra Capanoglu   +3 more
wiley   +1 more source

Foszforheterociklusok szintézise és hasznosítása = The synthesis and use of phosporus heterocycles [PDF]

, 2007
A kutatás három fő szálon futott, egyrészt az 5- és 6-tagú, másrészt a 7- és 8-tagú - ez utóbbi esetben áthidalt - P-heterociklusok területén, harmadrészt egy inverz Wittig-típusú reakció témájában.
Balázsdi Szabó, Nóra, Bat Amgalan, Namkhainyambuu, Farkas, Renáta, Forintos, Henrietta, Hegedűs, László, Imre, Tímea, Keglevich, György, Kovács, János, Körtvélyesi, Tamás, Ludányi, Krisztina, Novák, Tibor, Odinets, Irina Leonovna, Polonkáné Bálint, Ágnes, Sipos, Melinda, Stefan, Jankowski, Szelke, Helga, Szöllősy, Áron, Vinogradova, Natalya Mikchailovna, Vékey, Károly   +18 more
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