Results 91 to 100 of about 192,167 (361)
Lipid Exchangers: Cellular Functions and Mechanistic Links With Phosphoinositide Metabolism
Frontiers in Cell and Developmental Biology, 2020 Lipids are amphiphilic molecules that self-assemble to form biological membranes. Thousands of lipid species coexist in the cell and, once combined, define organelle identity.
Nicolas-Frédéric Lipp +3 more
doaj +1 more source
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells [PDF]
, 2016 The angiogenic inducer CCN1 (Cysteine-rich 61, CYR61) is differentially activated in metastatic breast carcinomas. However, little is known about the precise mechanisms that underlie the pro-metastatic actions of CCN1. Here, we investigated the impact of
Espinoza, Ingrid +3 more
core +1 more source
Experimental Biology and Medicine, 1957 Summary1. Urinary bladders of many species were analyzed for cholesterol and “fast-acting” (δ7) sterol. Rodents showed the highest content of (δ7) sterol, the dog an intermediate level, and livestock very little. In rodents and in the dog 60-84% of the δ7-sterol was 7-dehydrocholesterol. All bladder sterol was unesterified. 2. The sterols were found to
J S, FINLAYSON +2 more
openaire +2 more sources
Advanced Science, EarlyView.This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu +6 more
wiley +1 more source
Advanced Science, EarlyView.NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu +9 more
wiley +1 more source
Journal of Ginseng Research, 2018 Background: The Panax ginseng plant is used as an herbal medicine. Phytosterols of P. ginseng have inhibitory effects on inflammation-related factors in HepG2 cells. Methods: Phytosterols (e.g., stigmasterol and β-sitosterol) in the roots of P.
Dong Gu Lee +8 more
doaj +1 more source
Flagellar membrane association via interaction with lipid rafts [PDF]
, 2009 The eukaryotic flagellar membrane has a distinct composition from other domains of the plasmalemma. Our work shows that the specialized composition of the trypanosome flagellar membrane reflects increased concentrations of sterols and saturated fatty ...
Cieslak, John A. +6 more
core +2 more sources
CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, EarlyView.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
Turkish Journal of Agriculture: Food Science and Technology, 2017 Plant sterols are important agricultural products for human health and consequently, for nutrition industries. In the present study, free sterol contents of crude Turkish cottonseed oil samples have been determined in a single analytical run by using a ...
Cemile Özdemir Yücel +2 more
doaj +1 more source
Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †. [PDF]
, 2019 Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and ...
Cheng, Tina +3 more
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