Results 81 to 90 of about 193,847 (359)

The fatty acid and amino profiles, bioactive compounds, and alpha glucosidase inhibition activity of C. rheedei J.F. Gmelin seed oil☆

Oilseeds and fats, crops and lipids
C. rheedei J.F. Gmelin is an underutilized Asian shrub with no prior characterization of its seeds or oil. This study reports, for the first time, the nutritional and functional profile of C. rheedei seeds. The seeds yielded 32.6% oil, dominated by oleic
Pham Quoc Long, Nguyen Thi Nga, Dang Thi Minh Tuyet, Ly Dang Thi Phuong, Matthäus Bertrand, Nguyen Lan Nhi, Ha Dinh Thi, Thuy Duong Thi, Doan Lan Phuong   +8 more
doaj   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Cholesterol Sulfate: Pathophysiological Implications and Potential Therapeutics

Biomolecules
Cholesterol sulfate (CS) is a naturally occurring cholesterol derivative that is widely distributed across various tissues and body fluids. In humans, its biosynthesis is primarily mediated by the sulfotransferase (SULT) 2B1b (SULT2B1b).
Xiaoqian Yu, Siman Lei, Ying Shen, Tao Liu, Jun Li, Jia Wang, Zhiguang Su   +6 more
doaj   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Exploration of Hypolipidemic Effects of Sterols from Pleurotus tuber-regium(Fr.) Sing Sclerotium

Foods
The extraction technology of sterol was confirmed by ethanol reflux and saponification in this study. The orthogonal test was employed to assess the impact of extraction time, solid–liquid ratio, ethanol concentration and extraction temperature on the ...
Chao Wang, Yuan Liu, Yuting Duan, Haiping Lin   +3 more
doaj   +1 more source

A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample

Marine Drugs, 2012
A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I–K (2–4), and the known breviones (5–8), were isolated from the crude extract of a Penicillium sp.
Chengbin Cui, Yongsheng Che, Dezan Ye, Zongze Shao, Yan Li   +4 more
doaj   +1 more source

Preparation, Component Identification, and Antioxidant Activity of Anthocyanins From Punica granatum “Tunisia”

AgriFood: Journal of Agricultural Products for Food, EarlyView.
The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang, Xu‐han Yang, Meng‐qi Zhang, Xu Guo, Ning‐yang Li, Fang‐yu Long, Chao Liu   +6 more
wiley   +1 more source

Pharmacological activity of the fraction isolated from virgin olive oil containing the sterols and triterpenic alcohols

Grasas y Aceites, 1997
The fraction of sterols and triterpenic dialcohols from unsaponifiable of virgin olive oil has been tested for Its possible antiinflamatory activity. The topical administration of these products produced a potent antioedematous effect, in the auricular ...
R. de la Puerta, R. Maestro Durán, V. Ruiz Gutiérrez   +2 more
doaj   +1 more source

LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles

Frontiers in Microbiology, 2020
Lam proteins transport sterols between the membranes of different cellular compartments. In Saccharomyces cerevisiae, the LAM gene family consists of three pairs of paralogs.
Svyatoslav S. Sokolov, Margarita A. Vorobeva, Alexandra I. Smirnova, Alexandra I. Smirnova, Ekaterina A. Smirnova, Nataliya I. Trushina, Nataliya I. Trushina, Kseniia V. Galkina, Kseniia V. Galkina, Fedor F. Severin, Dmitry A. Knorre, Dmitry A. Knorre   +11 more
doaj   +1 more source

Expression of homoeologous molecular systems in wheat alloploids [PDF]

, 1976
Allopolyploidy is widespread in the plant kingdom, where it has been of considerable evolutionary significance. Although the existence of heterotic interactions between the genomes that make up an alloploid have been generally assumed, the precise nature
Aragoncillo Ballesteros, Cipriano, Carbonero Zalduegui, Pilar, Fernandez de Caleya, R., García Olmedo, Francisco, Torres, V.   +4 more
core   +1 more source