Results 61 to 70 of about 117,522 (314)
Advanced Science, EarlyView.Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An +8 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu +17 more
wiley +1 more source
Lipid Raft, Regulator of Plasmodesmal Callose Homeostasis
Plants, 2017 : The specialized plasma membrane microdomains known as lipid rafts are enriched by sterols and sphingolipids. Lipid rafts facilitate cellular signal transduction by controlling the assembly of signaling molecules and membrane protein trafficking ...
Arya Bagus Boedi Iswanto, Jae-Yean Kim
doaj +1 more source
AgriFood: Journal of Agricultural Products for Food, EarlyView.The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang +6 more
wiley +1 more source
Les acides gras estérifiés, les stérols et le squalène des enveloppes cellulaires de levure
OENO One, 1992 Ce travail se propose de doser les acides gras estérifiés, les stérols et le squalène dans deux échantillons d'écorces de levure du commerce de marques différentes.
Konrad Bernath, Alain Bertrand
doaj +1 more source
Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland +4 more
wiley +1 more source
Oilseeds and fats, crops and lipidsC. rheedei J.F. Gmelin is an underutilized Asian shrub with no prior characterization of its seeds or oil. This study reports, for the first time, the nutritional and functional profile of C. rheedei seeds. The seeds yielded 32.6% oil, dominated by oleic
Pham Quoc Long +8 more
doaj +1 more source
, 2004 Cholesterol homeostasis is established by a complex of three proteins, one of which contains a hydrophobic domain previously termed a sterol-sensing domain.
Levine, Tim
core +1 more source
Cholesterol Sulfate: Pathophysiological Implications and Potential Therapeutics
BiomoleculesCholesterol sulfate (CS) is a naturally occurring cholesterol derivative that is widely distributed across various tissues and body fluids. In humans, its biosynthesis is primarily mediated by the sulfotransferase (SULT) 2B1b (SULT2B1b).
Xiaoqian Yu +6 more
doaj +1 more source
Cardiovascular Safety of Plant Sterol and Stanol Consumption.
, 2015 Plant sterols and stanols as components of functional foods are widely used for cholesterol lowering. The regular intake of these functional foods is associated with a decrease in low density lipoprotein cholesterol of about 10 % and an increase in ...
Baumgartner, Iris +2 more
core +1 more source