Results 71 to 80 of about 126,548 (250)

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Cholesterol Sulfate: Pathophysiological Implications and Potential Therapeutics

Biomolecules
Cholesterol sulfate (CS) is a naturally occurring cholesterol derivative that is widely distributed across various tissues and body fluids. In humans, its biosynthesis is primarily mediated by the sulfotransferase (SULT) 2B1b (SULT2B1b).
Xiaoqian Yu, Siman Lei, Ying Shen, Tao Liu, Jun Li, Jia Wang, Zhiguang Su   +6 more
doaj   +1 more source

A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample

Marine Drugs, 2012
A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I–K (2–4), and the known breviones (5–8), were isolated from the crude extract of a Penicillium sp.
Chengbin Cui, Yongsheng Che, Dezan Ye, Zongze Shao, Yan Li   +4 more
doaj   +1 more source

Series of Concentration-Induced Phase Transitions in Cholesterol/Phosphatidylcholine Mixtures [PDF]

, 2013
In lipid membranes, temperature-induced transition from gel-to-fluid phase increases the lateral diffusion of the lipid molecules by three orders of magnitude.
István P. Sugár, Parkson L.-G. Chong, Sugár, István P., Chong, Parkson L.-G., István Simon, Chong, Parkson Lee-Gau, Simon, István   +6 more
core   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Exploration of Hypolipidemic Effects of Sterols from Pleurotus tuber-regium(Fr.) Sing Sclerotium

Foods
The extraction technology of sterol was confirmed by ethanol reflux and saponification in this study. The orthogonal test was employed to assess the impact of extraction time, solid–liquid ratio, ethanol concentration and extraction temperature on the ...
Chao Wang, Yuan Liu, Yuting Duan, Haiping Lin   +3 more
doaj   +1 more source

Pharmacological activity of the fraction isolated from virgin olive oil containing the sterols and triterpenic alcohols

Grasas y Aceites, 1997
The fraction of sterols and triterpenic dialcohols from unsaponifiable of virgin olive oil has been tested for Its possible antiinflamatory activity. The topical administration of these products produced a potent antioedematous effect, in the auricular ...
R. de la Puerta, R. Maestro Durán, V. Ruiz Gutiérrez   +2 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Improvement of determination of sterols in vegetable oils by gas chromatography

Liang you shipin ke-ji, 2019
On the basis of national standard method GB/T25223—2010, the method of determining sterols in animal and vegetable oils and fats by gas chromatography was improved and the preparation process of neutral aluminum oxide column was modified.
ZHANG Ying-xia, ZHANG Cheng, YANG Hui, ZHANG Liu-ping, QIANGuo-ping, ZHOU Zhou, ZHOU Shi-long, LOU Shi-long, ZHAO Dong-wang, WU Yin   +9 more
doaj   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source