Results 41 to 50 of about 192,167 (361)

Structure Prediction and Functional Characterization of ERG Proteins Involved in Ergosterol Biosynthetic Pathway of Candida albicans [PDF]

, 2011
The ERG proteins and enzymes of the ergosterol biosynthetic pathway has been the subject of intensive investigation as a target for several classes of antifungal agents used to treat C. albicans infection. Over the past few decades, a number of drugs and
Ashok Sharma, Suaib Luqman, Sudeep Roy   +2 more
core   +2 more sources

Sterol and Triterpene Profiles of the Callus Culture of Solanum mammosum

Makara Journal of Science, 2019
This study aimed to compare the sterol and triterpene profiles of two types of Solanum mammosum callus cultures, i.e., compact globular structure (CGS) and normal fine (F) calluses. The CGS callus resulted from the differentiation of the F callus culture
Silvy Juliana, Suciati Suciati, Gunawan Indrayanto   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The importance of choosing the appropriate cholesterol quantification method: enzymatic assay versus gas chromatography

Journal of Lipid Research
Cholesterol is a major lipid of the animal realm with many biological roles. It is an important component of cellular membranes and a precursor of steroid hormones and bile acids.
Jeanne Serrano, Lucy Martine, Yaël Grosjean, Niyazi Acar, Georges Alves, Elodie A.Y. Masson   +5 more
doaj   +1 more source

Sterols sense swelling in lipid bilayers [PDF]

, 1998
In the mimetic membrane system of phosphatidylcholine bilayers, thickening (pre-critical behavior, anomalous swelling) of the bilayers is observed, in the vicinity of the main transition, which is non-linear with temperature.
A. Blume, A. Guinier, C.R. Safinya, D. Needham, D.I. Svergun, E. Sackmann, F.Y. Chen, Frank Richter, G. Rapp, G. Rapp, G. Rapp, Gert Rapp, H.E. Stanley, H.I. Petrache, J. Lemmich, J. Lemmich, J.F. Nagle, J.F. Nagle, J.J. Binney, K. Gawrisch, L. Finegold, Leonard Finegold, M. Bloom, M. Rappolt, M.H. Hawton, M.J. Zuckermann, P. Meakin, P.C. Hohenberg, P.C. Hohenberg, P.G. de Gennes, R. Lipowsky, R. Lipowsky, R. Varma, R. Zhang, S. Matuoka, S. Mitaku, S.E. Rankin, S.M. Gruner, T. Taniguchi, T.J. McIntosh, W. Helfrich, W. Helfrich   +41 more
core   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Vertical distributions of lipid biomarkers in spring and summer in coastal regions of the East China Sea

Frontiers in Marine Science
Lipid biomarkers are amongst the most widely used proxies in studies of the structure and functioning of marine food webs. However, vertical distributions of lipid biomarkers and their controlling mechanisms remain unclear, especially in highly dynamic ...
Jiawei Gao, Jiawei Gao, Shulan Xu, Shulan Xu, Rong Bi, Rong Bi, Yaoyao Wang, Yang Ding, Yang Ding, Hong Che, Jing Zhang, Jing Zhang, Peng Yao, Peng Yao, Jie Shi, Jie Shi, Meixun Zhao, Meixun Zhao   +17 more
doaj   +1 more source

Les acides gras estérifiés, les stérols et le squalène des enveloppes cellulaires de levure

OENO One, 1992
Ce travail se propose de doser les acides gras estérifiés, les stérols et le squalène dans deux échantillons d'écorces de levure du commerce de marques différentes.
Konrad Bernath, Alain Bertrand
doaj   +1 more source

Phytophthora capsici sterol reductase PcDHCR7 has a role in mycelium development and pathogenicity

Open Biology, 2022
The de novo biosynthesis of sterols is critical for the majority of eukaryotes; however, some organisms lack this pathway, including most oomycetes. Phytophthora spp.
Weizhen Wang, Fan Zhang, Sicong Zhang, Zhaolin Xue, Linfang Xie, Francine Govers, Xili Liu   +6 more
doaj   +1 more source

Altered sterol metabolism in budding yeast affects mitochondrial iron–sulfur (Fe-S) cluster synthesis [PDF]

, 2018
Ergosterol synthesis is essential for cellular growth and viability of the budding yeast Saccharomyces cerevisiae, and intracellular sterol distribution and homeostasis are therefore highly regulated in this species. Erg25 is an iron-containing C4-methyl
Bard, Martin, Bhuiyan, Shah Alam, Chen, Opal S., Cox, James E., Kaplan, Jerry, Li, Liangtao, Natarajan, Selvamuthu K., Ward, Diane M.   +7 more
core   +1 more source