Results 81 to 90 of about 192,167 (361)

Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. [PDF]

, 2013
Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates ...
Bensinger, Steven J, York, Autumn G
core   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Improvement of determination of sterols in vegetable oils by gas chromatography

Liang you shipin ke-ji, 2019
On the basis of national standard method GB/T25223—2010, the method of determining sterols in animal and vegetable oils and fats by gas chromatography was improved and the preparation process of neutral aluminum oxide column was modified.
ZHANG Ying-xia, ZHANG Cheng, YANG Hui, ZHANG Liu-ping, QIANGuo-ping, ZHOU Zhou, ZHOU Shi-long, LOU Shi-long, ZHAO Dong-wang, WU Yin   +9 more
doaj   +1 more source

LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles

Frontiers in Microbiology, 2020
Lam proteins transport sterols between the membranes of different cellular compartments. In Saccharomyces cerevisiae, the LAM gene family consists of three pairs of paralogs.
Svyatoslav S. Sokolov, Margarita A. Vorobeva, Alexandra I. Smirnova, Alexandra I. Smirnova, Ekaterina A. Smirnova, Nataliya I. Trushina, Nataliya I. Trushina, Kseniia V. Galkina, Kseniia V. Galkina, Fedor F. Severin, Dmitry A. Knorre, Dmitry A. Knorre   +11 more
doaj   +1 more source

Hopanoids Play a Role in Membrane Integrity and pH Homeostasis in Rhodopseudomonas palustris TIE-1 [PDF]

, 2009
Sedimentary hopanes are pentacyclic triterpenoids that serve as biomarker proxies for bacteria and certain bacterial metabolisms, such as oxygenic photosynthesis and aerobic methanotrophy.
Hunter, Ryan C., Newman, Dianne K., Sessions, Alex L., Summons, Roger E., Welander, Paula V., Zhang, Lichun   +5 more
core   +3 more sources

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]

, 2018
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John, Edillor, Chantle R, Glass, Christopher K, Grossman, Tamar R, Henke, Adam, McDonald, Jeffrey G, Muse, Evan D, Ozeki, Katherine A, Roland, Jason T, Seidman, Jason S, Spann, Nathanael J, Tao, Jenhan, Thompson, Bonne M, Tremblay, Matthew S, Troutman, Ty D, Tsimikas, Sotirios, Yu, Shan   +16 more
core   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry

Journal of Lipid Research, 1999
A mass spectrometric method for the quantification of free cholesterol in cells and subcellular membranes is presented. The method is based on a simple one-step chemical derivatization of cholesterol to cholesterol-3-sulfate by a sulfur trioxide-pyridine
Roger Sandhoff, Britta Brügger, Dieter Jeckel, Wolf D. Lehmann, Felix T. Wieland   +4 more
doaj   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source