Results 171 to 180 of about 63,568 (310)

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Sterol flux rewiring: Cholesterol biosynthesis as a dynamic signaling network. [PDF]

J Biol Chem
Poirot M, de Médina P, Silvente-Poirot S.   +2 more
europepmc   +1 more source

Oxypaeoniflorin Attenuates Alcohol‐Associated Liver Disease, Potentially Involving TEAD4‐Mediated Inflammatory Signaling Cascades

Phytotherapy Research, EarlyView.
Oxypaeoniflorin (Opae) alleviates alcohol‐associated liver disease (ALD) by suppressing the TEAD4‐NLRP3 transcriptional axis. In hepatocytes, Opae inhibits YAP/TEAD4‐mediated NLRP3 inflammasome activation, thereby downregulating Lipin1/Srebp1‐associated lipid dysregulation.
Jiang‐Tao Zhong, Hao Yue, Ze‐Hao Wang, Ming Liu, Hai‐Ming Sun, Jian Song   +5 more
wiley   +1 more source

Tailoring plant-based food emulsions with oil bodies and proteins recovered by alkali aqueous extraction from rapeseed (<i>Brassica napus</i> L.) oilseeds. [PDF]

Curr Res Food Sci
Rabesona H, Lopez C.
europepmc   +1 more source

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Phytotherapy Research, EarlyView.
Leonurine inhibits PKM2 to remodel hepatocyte glycolysis, thereby alleviating liver injury in alcoholic hepatitis. ABSTRACT Alcoholic hepatitis (AH) is a liver disease caused by long‐term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis.
Xuan‐Xuan Zhang, Gao‐Feng Pan, Hong Fang, Xiao‐Peng Liu, Jing Sun, Ji‐Xiang Chen, Xin Fan, Jia‐Hao Feng   +7 more
wiley   +1 more source

A sterol reductase responsible for the unusual 8(14)-unsaturation in bacterial sterol production and degradation. [PDF]

J Bacteriol
Lee AK, Giner J-L, Welander PV.
europepmc   +1 more source

Magnoflorine Ameliorates MASH in Mice Fed a High‐Fat and High‐Fructose Diet by Promoting AMPK‐Mediated Lipophagy and Fatty Acid Oxidation

Phytotherapy Research, EarlyView.
Magnoflorine ameliorates metabolic dysfunction‐associated steatohepatitis by promoting AMPKα‐mediated lipophagy and fatty acid oxidation. ABSTRACT Emerging as a significant clinical burden, metabolic dysfunction‐associated steatohepatitis (MASH) continues to challenge global healthcare systems due to limited effective interventions.
Zhengjie Lu, Tongyun Mao, Longxin Chai, Kaiqi Chen, Kexin Liu, Cong Zhang, Hao Kou   +6 more
wiley   +1 more source

Effects of flaxseed germination on oil composition, tissue n-3 fatty acid profiles, and brain lipidomics in mice. [PDF]

Food Chem X
Huang Z, Xu S, Li Y, Huang K, Liu C, Gao Y, Li Q, Yu X.   +7 more
europepmc   +1 more source

Betulinic Acid Counteracts Statin‐Induced PCSK9 Upregulation Through FXR/SHP‐Associated Signaling

Phytotherapy Research, EarlyView.
Betulinic acid attenuates atorvastatin‐induced increases in PCSK9 expression and secretion while maintaining or increasing LDLR expression in hepatocyte‐derived cells. Mechanistic studies support the involvement of FXR/SHP signaling and show increased SHP–SREBP2 association.
Chan‐Woong Park, Mingoo Bae, Pureum Kang, Na Young Lee, Ja Hyun Koo, Young Hee Choi, Young‐Won Chin   +6 more
wiley   +1 more source

Structure-activity relationship of adipate-bridged <i>β</i>-sitosterol glycosyl derivatives as novel cholesterol alternatives for liposome stabilization. [PDF]

Curr Res Food Sci
Hu Y, Zhang X, Zhou Y, Du H, Sun S.
europepmc   +1 more source