Results 211 to 220 of about 61,990 (306)

Rab geranylgeranyl transferase activity is required for proper sterol biosynthesis in Arabidopsis thaliana. [PDF]

Plant Cell Physiol
Gutkowska M, Zajbt-Łuczniewska M, Buszewicz D, Anielska-Mazur A, Lipko A, Pączkowski C, Spólnik G, Sojka M, Jaźwiec R, Samborowska E, Swiezewska E, Hoffman M.   +11 more
europepmc   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Camellia-Derived Bioactive Compounds: Research Advances and Application Prospects in Dermatology. [PDF]

Int J Mol Sci
Zhang L, Dai B, Shen H, Chen S, Zhang W.
europepmc   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

The azole-resistance phenotype of a <i>Nakaseomyces glabratus</i> clinical strain encoding a wild-type <i>PDR1</i> allele involves the efflux pumps Aus1 and Pdh1 and Cyb5, an alternative reductase required for ergosterol biosynthesis. [PDF]

Microbiol Spectr
Pinheiro MJ, Parker JE, Ferreira MT, Fernandes F, Mira NP.   +4 more
europepmc   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast. [PDF]

Cells
Barone F, Cottier S, Stribny J, Visentin M, Schneiter R, Lone MA.   +5 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Farnesol and geranylgeraniol in plant reproduction: insights from Arabidopsis and beyond. [PDF]

J Exp Bot
Gutkowska M, Swiezewska E, Rojek J.
europepmc   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source