Results 1 to 10 of about 7,281 (146)
Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women’s Health Research [PDF]
Metabolites, 2022 The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-
Ajna Hamidovic +5 more
doaj +3 more sources
Long‐lasting effects of chronic exposure to chemical pollution on the hologenome of the Manila clam [PDF]
Evolutionary Applications, Volume 14, Issue 12, Page 2864-2880, December 2021., 2021 Abstract Chronic exposure to pollutants affects natural populations, creating specific molecular and biochemical signatures. In the present study, we tested the hypothesis that chronic exposure to pollutants might have substantial effects on the Manila clam hologenome long after removal from contaminated sites.
Mariangela Iannello +23 more
wiley +3 more sources
Placental proteomic signatures of preterm birth, gestational age, and birthweight [PDF]
BMC Pregnancy and ChildbirthBackground Preterm birth and low birthweight are leading contributors to infant morbidity and mortality, yet underlying mechanisms remain poorly understood.
Brennan H. Baker +11 more
doaj +2 more sources
Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes [PDF]
Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016 Traditional Chinese medicine (TCM) still needs more scientific rationale to be proven for it to be accepted further in the West. We are now in the position to propose computational hypotheses for the mode‐of‐actions (MOAs) of 45 TCM therapeutic action (sub)classes from in silico target prediction algorithms, whose target was later annotated with Kyoto ...
Siti Zuraidah Mohamad Zobir +7 more
wiley +8 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Objective. Salvianolic acid A, a natural polyphenolic ingredient extracted from traditional Chinese medicine, possesses an excellent pharmacological activity against cardiovascular diseases. Herein, therapeutic mechanisms of salvianolic acid A in myocardial infarction were explored through systematic and comprehensive network pharmacology analyses ...
Qing Huang +5 more
wiley +1 more source
Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology
Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020 Oroxylum indicum (O. indicum) is an important traditional Chinese medicine that exerts a wide spectrum of pharmacological activities. However, the pharmacological effect of O. indicum and its mechanism of action have not to be systematically elucidated yet. In this study, the druggability for active compounds of O.
Junmin Chen +3 more
wiley +1 more source
Stem Cells International, Volume 2019, Issue 1, 2019., 2019 Adipose‐derived mesenchymal stem cells (MSC‐ATs) are representative cell sources for cell therapy. However, how cell stress resulting from passage influences the MSC‐AT protein expression has been unclear. In this study, a protein expression analysis was performed by liquid chromatography with tandem mass spectrometry (LC‐MS/MS) using mouse primary ...
Yoshiki Nakashima +9 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019 Lung cancer is the most common cause of cancer death with high morbidity and mortality, which non‐small‐cell lung cancer (NSCLC) accounting for the majority. Traditional Chinese Medicine (TCM) is effective in the treatment of complex diseases, especially cancer. However, TCM is still in the conceptual stage. The interaction between different components
Xing Su +10 more
wiley +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.Epidemiological studies identify risk factors for Alzheimer’s disease (AD), which induces oxidative stress and inflammation. Pharmaceuticals aimed against the nuclear receptor PPARγ, including TZDs, have been associated with considerable negative consequences in AD treatment.
Tassanee Ongtanasup +4 more
wiley +1 more source