The role of protein oxidation in ageing & disease [PDF]
Ageing is a natural phenomenon of the human lifecycle, yet it is still not understood what causes the deterioration of the human body near the end of the lifespan.
Pasha, Sabah
core +1 more source
Journal of Inherited Metabolic Disease, 2020 Multiple Sulfatase Deficiency (MSD, MIM#272200) is an ultra‐rare lysosomal storage disorder arising from mutations in the SUMF1 gene, which encodes the formylglycine‐generating enzyme (FGE).
Lars Schlotawa +6 more
semanticscholar +1 more source
A Support Vector Machine Base Model for Predicting Heparin-Binding Proteins Using Biological Metrics and XB Patterns as Features [PDF]
, 2016 Heparin is a highly sulphated and negatively charged polysaccharides belonging to the glycosamino- glycans(GAGs) family. It is widely used in medical treatments as an injectable anticoagulant.
Sirrianni, Joseph W
core +1 more source
The schlafen core domain: from structure to function [PDF]
, 2018 The immune system is a complex network of processes and structures to protect the organism against infectious diseases. All processes, which include the maturation of individual immune cells, must be strictly regulated to prevent malfunction.
Huber, Elisabeth
core +2 more sources
Changes in the Proteome of the Circle of Willis during Aging Reveal Signatures of Vascular Disease
Oxidative Medicine and Cellular Longevity, Volume 2024, Issue 1, 2024.Approximately 70% of all strokes occur in patients over 65 years old, and stroke increases the risk of developing dementia. The circle of Willis (CoW), the ring of arteries at the base of the brain, links the intracerebral arteries to one another to maintain adequate cerebral perfusion.
Vikram Subramanian +6 more
wiley +1 more source
Structure, metabolism and biological functions of steryl glycosides in mammals
Biochemical Journal, 2020 Steryl glycosides (SGs) are sterols glycosylated at their 3β-hydroxy group. They are widely distributed in plants, algae, and fungi, but are relatively rare in bacteria and animals.
M. Shimamura
semanticscholar +1 more source
Synthesis of Steryl Hydroxycinnamates to Enhance Antioxidant Activity of Rapeseed Oil and Emulsions
Materials, 2020 In recent years, steryl esters have found potential applications in food, pharmaceutical and cosmetic industries. Therefore, three hydroxycinnamate steryl esters (HSEs): β-sitosteryl sinapate (β-SSA), β-sitosteryl caffeate (β-SCA), and β-sitosteryl ...
Dobrochna Rabiej-Kozioł +2 more
semanticscholar +1 more source
Study of the Evolutionary Role of Nitric Oxide (NO) in the Cephalochordate Amphioxus, “Branchiostoma lanceolatum” [PDF]
, 2018 Nitric Oxide (NO) is a gaseous molecule that acts in a wide range of biological processes. NO can be produced by enzymatic and non-enzymatic pathways and, in this scenario, the enzyme Nitric Oxide Synthase (NOS) has a great importance for its exclusive ...
Caccavale, Filomena
core +1 more source
Analyse des Mutationsspektrums bei 46,XY Differences of Sex Development : Nachweis der endocytotischen Rezeptoren LRP2 und LMBR1L sowie des Gens KISS1 [PDF]
, 2023 Für 16 Individuen mit Differences of Sex Development (DSD) wurden Exome sequenziert, um für jeden Fall mittels zugrunde liegender Genmutation die Entstehung des jeweiligen DSD-Phänotyps erklären zu können.
Marko, Hannah Lea
core +1 more source
Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
Nature Communications, 2017 Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.
Mykhaylo Demydchuk +7 more
semanticscholar +1 more source