Characterization of human placental tissue and cell lines for their xenobiotic and steroid disposition potential through quantitative proteomics [PDF]
The placenta is a vital fetal endocrine organ that plays an important role in gas, nutrient, and hormone shuttling between maternal and fetal sides, but much is unknown about the placental functions due to logistical, ethical, and technical challenges in
Kruger, Laken
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Evaluating the effects of PCBs in non-alcoholic fatty liver disease & diabetes and the role of AhR in regulating the hepatic proteome and lipid metabolism. [PDF]
, 2020 Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) and diabetes. Based on their ability to activate the aryl hydrocarbon receptor (AhR), PCBs are subdivided into two classes ...
Jin, Jian
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A SEQUENTIAL DUAL CLEAVAGE OF THE ARYLSULFAMATE LINKER TO PROVIDE BOTH SULFAMATE AND PHENOL DERIVATIVES [PDF]
, 2015 . Tyramine sulfamate was linked to the trityl chloride resin and this polymeric solid support used to introduce two levels of molecular diversity by formation of peptide bonds.
Diane Fournier +2 more
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Frontiers in Chemistry, 2018 Dietary plant foods are characterized by a vast molecular diversity of glycosylated sterols (SG) that differ in the structure of the steryl backbone.
Linda H Münger, S. Boulos, L. Nyström
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Regulation of Steroid Sulfatase by Glucocorticoids in Human Breast Cancer and Bone Cancer Cell Lines [PDF]
, 2007 Steroid sulfatase is an enzyme involved in the conversion of active estrogens and androgens from inactive systemic precursors such as estrone sulfate (E1S) and dehydropiandrosterone sulfate (DHEAS).
Barua, Suman
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정량 단백체학 기술을 이용한 췌관선암 조직에서의 위험군 예측용 다중 바이오마커 어세이 개발 [PDF]
, 2021 학위논문(박사) -- 서울대학교대학원 : 공과대학 협동과정 바이오엔지니어링전공, 2021.8. 김영수.Purpose: Pancreatic ductal adenocarcinoma (PDAC) subtypes have been identified using various methodologies.
손민수
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Characterization of Steroid Sulfatase in Human and Mouse Tissues and in the Mouse MC3T3-E1 Pre-Osteoblastic Cell Line [PDF]
, 2007 Steroid sulfatase cleaves the sulfate group from 3Β-hydroxysteroid sulfates. This enzyme is widely distributed among mammalian tissues, and it has been suggested to play a role in the in situ conversion of inactive steroids to active forms in a variety ...
DiFrancesca, Heidi
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The Regulation of Steroid Action by Sulfation and Desulfation [PDF]
, 2015 Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite circulatory transit.
Arlt, Wiebke +4 more
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Breast Cancer Research and Treatment, 2017 PurposeIrosustat is a first-generation, orally active, irreversible steroid sulfatase inhibitor. We performed a multicentre, open label phase II trial of the addition of Irosustat to a first-line aromatase inhibitor (AI) in patients with advanced BC to ...
C. Palmieri +17 more
semanticscholar +1 more source
OncoTarget, 2017 Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms.
Sangyun Shin +7 more
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