Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea Anemone Stichodactyla helianthus. [PDF]
Int J Mol Sci, 2020 Venoms constitute complex mixtures of many different molecules arising from evolution in processes driven by continuous prey–predator interactions. One of the most common compounds in these venomous cocktails are pore-forming proteins, a family of toxins whose activity relies on the disruption of the plasmatic membranes by forming pores.
Rivera-de-Torre E +5 more
europepmc +8 more sources
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. [PDF]
PLoS ONE, 2023 Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3 ...
Yuqing Wang +7 more
doaj +4 more sources
Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus. [PDF]
Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 The BPTI/Kunitz-type inhibitor family includes several extremely potent serine protease inhibitors. To date, the inhibitory mechanisms have only been studied for mammalian inhibitors. Here, the first crystal structure of a BPTI/Kunitz-type inhibitor from a marine invertebrate (rShPI-1A) is reported to 2.5 Å resolution.
García-Fernández R +8 more
europepmc +5 more sources
Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family [PDF]
BMC Biology, 2023 Background The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in Actiniarians remain uncharacterised. One such peptide family, sea anemone 8 (SA8),
Lauren M. Ashwood +22 more
doaj +2 more sources
Revista Cubana de Hematología, Inmunología y Hemoterapia, 1999 Las citolisinas Sticholysina I (St I) y Sticholysina II (St II) inducen la agregación plaquetaria en el plasma rico en plaquetas en el rango de concentraciones ensayadas (0,5 a 10 µg/mL).
Alina Díaz Concepción +6 more
doaj +2 more sources
Effects of lipid composition on membrane permeabilization by sticholysin I and II, two cytolysins of the sea anemone Stichodactyla helianthus. [PDF]
Biophys J, 2001 Sticholysin I and II (St I and St II), two basic cytolysins purified from the Caribbean sea anemone Stichodactyla helianthus, efficiently permeabilize lipid vesicles by forming pores in their membranes. A general characteristic of these toxins is their preference for membranes containing sphingomyelin (SM).
Valcarcel CA +8 more
europepmc +5 more sources
Two-dimensional crystallization on lipid monolayers and three-dimensional structure of sticholysin II, a cytolysin from the sea anemone Stichodactyla helianthus. [PDF]
Biophys J, 2000 Sticholysin II (Stn II), a potent cytolytic protein isolated from the sea anemone Stichodactyla helianthus, has been crystallized on lipid monolayers. With Fourier-based methods, a three-dimensional (3D) model of Stn II, up to a resolution of 15 A, has been determined. The two-sided plane group is p22(1)2, with dimensions a = 98 A, b = 196 A.
Martín-Benito J +5 more
europepmc +4 more sources
Sticholysin I–II oligomerization in the absence of membranes
FEBS Letters, Volume 596, Issue 8, Page 1029-1036, April 2022., 2022 In this study, the oligomerization in solution of StnI and StnII, two pore‐forming toxins produced by Stichodactyla helianthus, has been studied using analytical ultracentrifugation. Our results show that while StnI is more prone to oligomerize than StnII when assayed independently, the addition of a small amount of StnII favours oligomerization ...
Sara García‐Linares +8 more
wiley +1 more source
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges
Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021 Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič +9 more
wiley +1 more source
Omics‐based molecular analyses of adhesion by aquatic invertebrates
Biological Reviews, Volume 96, Issue 3, Page 1051-1075, June 2021., 2021 ABSTRACT Many aquatic invertebrates are associated with surfaces, using adhesives to attach to the substratum for locomotion, prey capture, reproduction, building or defence. Their intriguing and sophisticated biological glues have been the focus of study for decades.
Peter A. Davey +14 more
wiley +1 more source