Results 1 to 10 of about 1,026 (176)

Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. [PDF]

PLoS ONE, 2023
Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3 ...
Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton   +7 more
doaj   +7 more sources

Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea Anemone Stichodactyla helianthus. [PDF]

Int J Mol Sci, 2020
Venoms constitute complex mixtures of many different molecules arising from evolution in processes driven by continuous prey–predator interactions. One of the most common compounds in these venomous cocktails are pore-forming proteins, a family of toxins whose activity relies on the disruption of the plasmatic membranes by forming pores.
Rivera-de-Torre E, Palacios-Ortega J, Slotte JP, Gavilanes JG, Martínez-Del-Pozo Á, García-Linares S.   +5 more
europepmc   +10 more sources

Stichodactyla helianthus' de novo transcriptome assembly: Discovery of a new actinoporin isoform [PDF]

Toxicon, 2018
Transcriptomic profiling of venom producing tissues from different animals is an effective approach for discovering new toxins useful in biotechnological and pharmaceutical applications, as well in evolutionary comparative studies of venomous animals ...
Garb, Jessica E., Martínez del Pozo, Álvaro, Rivera de Torre, Esperanza   +2 more
core   +9 more sources

Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus. [PDF]

Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
The BPTI/Kunitz-type inhibitor family includes several extremely potent serine protease inhibitors. To date, the inhibitory mechanisms have only been studied for mammalian inhibitors. Here, the first crystal structure of a BPTI/Kunitz-type inhibitor from a marine invertebrate (rShPI-1A) is reported to 2.5 Å resolution.
García-Fernández R, Pons T, Meyer A, Perbandt M, González-González Y, Gil D, de los Angeles Chávez M, Betzel C, Redecke L.   +8 more
europepmc   +7 more sources

Effects of lipid composition on membrane permeabilization by sticholysin I and II, two cytolysins of the sea anemone Stichodactyla helianthus. [PDF]

Biophys J, 2001
Sticholysin I and II (St I and St II), two basic cytolysins purified from the Caribbean sea anemone Stichodactyla helianthus, efficiently permeabilize lipid vesicles by forming pores in their membranes. A general characteristic of these toxins is their preference for membranes containing sphingomyelin (SM).
Valcarcel CA, Dalla Serra M, Potrich C, Bernhart I, Tejuca M, Martinez D, Pazos F, Lanio ME, Menestrina G.   +8 more
europepmc   +6 more sources

The Effect of Cholesterol on the Long-Range Network of Interactions Established among Sea Anemone Sticholysin II Residues at the Water-Membrane Interface [PDF]

Marine Drugs, 2015
Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members.
Sara García-Linares, Ida Alm, Terhi Maula, José G. Gavilanes, Johan Peter Slotte, Álvaro Martínez-del-Pozo   +5 more
doaj   +7 more sources

The Mitochondrial Genome of the Sea Anemone Stichodactyla haddoni Reveals Catalytic Introns, Insertion-Like Element, and Unexpected Phylogeny. [PDF]

Life (Basel), 2021
A hallmark of sea anemone mitochondrial genomes (mitogenomes) is the presence of complex catalytic group I introns. Here, we report the complete mitogenome and corresponding transcriptome of the carpet sea anemone Stichodactyla haddoni (family ...
Johansen SD, Chi SI, Dubin A, Jørgensen TE.   +3 more
europepmc   +4 more sources

Screening and cDNA Cloning of Kv1 Potassium Channel Toxins in Sea Anemones [PDF]

Marine Drugs, 2010
When 21 species of sea anemones were screened for Kv1 potassium channel toxins by competitive inhibition of the binding of 125I-α-dendrotoxin to rat synaptosomal membranes, 11 species (two species of Actiniidae, one species of Hormathiidae, five species ...
Kazuo Shiomi, Yuji Nagashima, Tomohiro Honma, Yuichi Hasegawa, Yoshikazu Yamaguchi   +4 more
doaj   +4 more sources

Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family [PDF]

BMC Biology, 2023
Background The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in Actiniarians remain uncharacterised. One such peptide family, sea anemone 8 (SA8),
Lauren M. Ashwood, Khaled A. Elnahriry, Zachary K. Stewart, Thomas Shafee, Muhammad Umair Naseem, Tibor G. Szanto, Chloé A. van der Burg, Hayden L. Smith, Joachim M. Surm, Eivind A. B. Undheim, Bruno Madio, Brett R. Hamilton, Shaodong Guo, Dorothy C. C. Wai, Victoria L. Coyne, Matthew J. Phillips, Kevin J. Dudley, David A. Hurwood, Gyorgy Panyi, Glenn F. King, Ana Pavasovic, Raymond S. Norton, Peter J. Prentis   +22 more
doaj   +2 more sources

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3. [PDF]

FEBS J, 2015
Chang SC, Huq R, Chhabra S, Beeton C, Pennington MW, Smith BJ, Norton RS.   +6 more
europepmc   +3 more sources