Results 31 to 40 of about 13,996 (89)

ShK‐modified UCMSCs Inhibit M1‐Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis

Advanced Science, Volume 12, Issue 9, March 6, 2025.
Bioengineered UCMSCs are developed that enabled the production of a peptide secretion, ShK. The secreted peptide is functional in blocking Kv1.3 channels and suppressing the activation of macrophages in vitro and in vivo, which can provide potential treatments to halt osteoarthritis progression. The strategy provided a new idea for engineered stem cell
Wenshu Wu, Xueying An, Wang Gong, Lin Yang, Na Liu, Bin Liu, Baosheng Guo, Qing Jiang, Lan Li   +8 more
wiley   +1 more source

Analyse génétique des réponses physiologiques du tournesol (Helianthus annuus L.) soumis à la sécheresse [PDF]

, 2007
Afin de progresser dans la compréhension des caractères clés impliqués dans les processus de tolérance à la sécheresse chez le tournesol, nous avons réalisé plusieurs expérimentations, en conditions contrôlées et au champ sur des populations de tournesol
Poormohammad Kiani, Seifollah
core   +1 more source

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

Marine Drugs, 2015
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM.
Michael W. Pennington, Shih Chieh Chang, Satendra Chauhan, Redwan Huq, Rajeev B. Tajhya, Sandeep Chhabra, Raymond S. Norton, Christine Beeton   +7 more
doaj   +1 more source

Structure–function relationships in ShKT domain peptides: ShKT‐Ts1 from the sea anemone Telmatactis stephensoni

Proteins: Structure, Function, and Bioinformatics, Volume 92, Issue 2, Page 192-205, February 2024.
Abstract Diverse structural scaffolds have been described in peptides from sea anemones, with the ShKT domain being a common scaffold first identified in ShK toxin from Stichodactyla helianthus. ShK is a potent blocker of voltage‐gated potassium channels (KV1.x), and an analog, ShK‐186 (dalazatide), has completed Phase 1 clinical trials in plaque ...
Karoline Sanches, Lauren M. Ashwood, Abisola Ave‐Maria Olushola‐Siedoks, Dorothy C. C. Wai, Arfatur Rahman, Kashmala Shakeel, Muhammad Umair Naseem, Gyorgy Panyi, Peter J. Prentis, Raymond S. Norton   +9 more
wiley   +1 more source

Application of stichodactyla toxin in the treatment of autoimmune diseases

, 2018
Stichodactyla helianthus (Ellis, 1768) je vrsta vlasulje prisutna u Karipskom moru. Sadrži neurotoksine koji prvenstveno služe za obranu od predatora. Proučavanje peptida ShK iz ove vrste pokazalo je da osim toksičnog učinka postoji i moguća terapeutska ...
Bovan, Srećko
core   +2 more sources

Morphology and phylogeny of the sea anemone Stichodactyla haddoni (Cnidaria: Anthozoa: Actiniaria) from Chabahar Bay, Iran [PDF]

, 2015
Carpet anemones of the genus Stichodactyla are characterized by having no calcium carbonate skeleton, being flattened with rather short tentacles, being exclusively tropical, and being hosts for clown fish species.
Attaran-Fariman, Gilan, Attaran-Farimin, Gilan, Javid, Pegah, Shakouri, Arash   +3 more
core   +1 more source

Sticholisina II encapsulada en liposomas potencia una respuesta de linfocitos T citotóxicos específica al antígeno

Anales de la Academia de Ciencias de Cuba, 2021
Introducción: Las estrategias vacunales para potenciar respuestas de linfocitos T CD8+ citotóxicos (CTL) constituyen un reto debido a la necesidad de favorecer la presentación cruzada de antígenos (Ag) exógenos por las células presentadoras de antígenos (
María Eliana Lanio Ruiz, Rady Judith Laborde Quintana, Yoelys Cruz Leal, Luis Enrique Fernández Molina, Oraly Sánchez Ferrás, Anaixis del Valle, Isbel Lopetegui González, María C. Luzardo Lorenzo, Carlos Álvarez Valcárcel, Circe Mesa   +9 more
doaj  

Peptide fingerprinting of the neurotoxic fractions isolated from the secretions of sea anemones Stichodactyla helianthus and Bunodosoma granulifera. New members of the APETx-like family identified by a 454 pyrosequencing approach [PDF]

, 2012
Sea anemones are known to contain a wide diversity of biologically active peptides, mostly unexplored according to recent peptidomic and transcriptomic studies.
Pimenta, Adriano M. C., Pimenta, Adriano M.C., Juliana Silva Cassoli, Anoland Garateix, Zaharenko, Andre J., Adriano M.C. Pimenta, André J. Zaharenko, Konno, Katsuhiro, José Carlos de Freitas, Fei Sa, Rodríguez, Armando Alexei, Konnoe, Katsuhiro, Zhi Qiang Dong, Maria Elena de Lima, Katsuhiro Konno, Garateix, Anoland, de Lima, Maria Elena, Dong, Zhi Qiang, Lee, Simon Ming Yuen, Sa, Fei, Alexei Rodriguez, Armando, Simon Ming Yuen Lee, de Freitas, Jose Carlos, Armando Alexei Rodríguez, Cassoli, Juliana Silva   +24 more
core   +1 more source

Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans

Molecules and Cells
: Organismal survival depends on coordinated responses to oxidative stress and DNA damage. Using Caenorhabditis elegans, we investigate mul-1, a robust transcriptional target of ionizing radiation and reactive oxygen species.
Emilio Carranza-García, Abe Gayle Santos, Kyoung-Hye Yoon, Anton Gartner   +3 more
doaj   +1 more source

N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3 [PDF]

, 2015
The voltage-gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone peptide K+-channel toxin from Stichodactyla helianthus (ShK) inhibits the proliferation of effector
Pennington, Michael W, Huq, Redwan, Beeton, Christine, Chhabra, Sandeep, Norton, Raymond S, Chang, Shih C, Smith, Brian J   +6 more
core   +1 more source