Results 21 to 30 of about 13,996 (89)

Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

Toxins, 2018
Sea anemones have been understudied as a source of peptide and protein toxins, with relatively few examined as a source of new pharmacological tools or therapeutic leads. This is surprising given the success of some anemone peptides that have been tested,
Peter J. Prentis, Ana Pavasovic, Raymond S. Norton   +2 more
doaj   +1 more source

Peptide Fraction pOh2 Exerts Antiadipogenic Activity through Inhibition of C/EBP‐α and PPAR‐γ Expression in 3T3‐L1 Adipocytes

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Many studies have comprehensively examined the venom of Ophiophagus hannah snake. Its venom comprises different compounds exhibiting a wide range of pharmacological activities. In this investigation, four peptide fractions (PFs), ranging from 3 kDa to 10 kDa, isolated from the Vietnamese snake venom of O.
Thi Tuyet Nhung Nguyen, Thi Thu Ha, Thi Hoa Nguyen, Thi Hien Vu, Nam Hai Truong, Hoang Ha Chu, Dong Van Quyen, Gian L. Mariottini   +7 more
wiley   +1 more source

Partially Purified Extracts of Sea Anemone Anemonia viridis Affect the Growth and Viability of Selected Tumour Cell Lines

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis ...
Matteo Bulati, Alessandra Longo, Tiziana Masullo, Sara Vlah, Carmelo Bennici, Angela Bonura, Monica Salamone, Marcello Tagliavia, Aldo Nicosia, Salvatore Mazzola, Paolo Colombo, Angela Cuttitta, Michael Kalafatis   +12 more
wiley   +1 more source

Roles of Lymphocyte Kv1.3‐Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels

Mediators of Inflammation, Volume 2015, Issue 1, 2015., 2015
Delayed rectifier K+‐channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch‐clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo studies then revealed the clinically ...
Itsuro Kazama, Augusto Vaglio
wiley   +1 more source

Two-Dimensional Crystallization on Lipid Monolayers and Three-Dimensional Structure of Sticholysin II, a Cytolysin from the Sea Anemone Stichodactyla helianthus [PDF]

, 2000
Sticholysin II (Stn II), a potent cytolytic protein isolated from the sea anemone Stichodactyla helianthus, has been crystallized on lipid monolayers. With Fourier-based methods, a three-dimensional (3D) model of Stn II, up to a resolution of 15Å, has ...
Gavilanes, Francisco, Mancheño, José M., Martín-Benito, Jaime, Fernández, José J., de los Ríos, Vivian, Gavilanes, José G.   +5 more
core   +1 more source

Magnificamide, a β-Defensin-Like Peptide from the Mucus of the Sea Anemone Heteractis magnifica, Is a Strong Inhibitor of Mammalian α-Amylases

Marine Drugs, 2019
Sea anemones’ venom is rich in peptides acting on different biological targets, mainly on cytoplasmic membranes and ion channels. These animals are also a source of pancreatic α-amylase inhibitors, which have the ability to control the glucose
Oksana Sintsova, Irina Gladkikh, Aleksandr Kalinovskii, Elena Zelepuga, Margarita Monastyrnaya, Natalia Kim, Lyudmila Shevchenko, Steve Peigneur, Jan Tytgat, Emma Kozlovskaya, Elena Leychenko   +10 more
doaj   +1 more source

Scorpion Peptides: Potential Use for New Drug Development

Journal of Toxicology, Volume 2013, Issue 1, 2013., 2013
Several peptides contained in scorpion fluids showed diverse array of biological activities with high specificities to their targeted sites. Many investigations outlined their potent effects against microbes and showed their potential to modulate various biological mechanisms that are involved in immune, nervous, cardiovascular, and neoplastic diseases.
BenNasr Hmed, Hammami Turky Serria, Zeghal Khaled Mounir, Robert Tanguay   +3 more
wiley   +1 more source

Stichodactyla helianthus Ellis 1768

, 2012
Stichodactyla helianthus (Ellis, 1768) (Figure 8, Table 2) Actinia helianthus Ellis, 1768: 436. Actinia Helianthus [sic] Ellis & Solander, 1786: 6 –7. Actinia Anemone [sic] Ellis & Solander, 1786: 6. Discosoma anemone Duchassaing, 1850: 9.
Segura-Puertas, Lourdes, Simões, Nuno, Sanchez-Rodriguez, Judith, Gonzalez-Muñoz, Ricardo, Rodriguez, Estefania   +4 more
core   +1 more source

The Effect of Cholesterol on the Long-Range Network of Interactions Established among Sea Anemone Sticholysin II Residues at the Water-Membrane Interface

Marine Drugs, 2015
Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members.
Sara García-Linares, Ida Alm, Terhi Maula, José G. Gavilanes, Johan Peter Slotte, Álvaro Martínez-del-Pozo   +5 more
doaj   +1 more source

The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels

Toxins, 2016
The bovine pancreatic trypsin inhibitor (BPTI)-Kunitz-type protein ShPI-1 (UniProt: P31713) is the major protease inhibitor from the sea anemone Stichodactyla helianthus.
Rossana García-Fernández, Steve Peigneur, Tirso Pons, Carlos Alvarez, Lidice González, María A. Chávez, Jan Tytgat   +6 more
doaj   +1 more source