Results 21 to 30 of about 20,141 (153)
Revista Cubana de Hematología, Inmunología y Hemoterapia, 1999 Las citolisinas Sticholysina I (St I) y Sticholysina II (St II) inducen la agregación plaquetaria en el plasma rico en plaquetas en el rango de concentraciones ensayadas (0,5 a 10 µg/mL).
Alina Díaz Concepción +6 more
doaj +2 more sources
Peptides, 2012 Sea anemones are known to contain a wide diversity of biologically active peptides, mostly unexplored according to recent peptidomic and transcriptomic studies.
A. Rodríguez +10 more
semanticscholar +2 more sources
N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3. [PDF]
FEBS J, 2015 The voltage-gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone peptide K+-channel toxin from Stichodactyla helianthus (ShK) inhibits the proliferation of effector
Chang SC +6 more
europepmc +2 more sources
Toxicon, 2009 Sticholysins (Sts) I and II (StI/II) are pore-forming toxins (PFTs) produced by the Caribbean Sea anemone Stichodactyla helianthus belonging to the actinoporin family, a unique class of eukaryotic PFTs exclusively found in sea anemones. As for the rest of the members of this family, Sts are cysteine-less proteins, with molecular weights around 20 kDa ...
C. Álvarez +5 more
semanticscholar +3 more sources
Sticholysin I–II oligomerization in the absence of membranes
FEBS Letters, Volume 596, Issue 8, Page 1029-1036, April 2022., 2022 In this study, the oligomerization in solution of StnI and StnII, two pore‐forming toxins produced by Stichodactyla helianthus, has been studied using analytical ultracentrifugation. Our results show that while StnI is more prone to oligomerize than StnII when assayed independently, the addition of a small amount of StnII favours oligomerization ...
Sara García‐Linares +8 more
wiley +1 more source
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges
Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021 Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič +9 more
wiley +1 more source
Omics‐based molecular analyses of adhesion by aquatic invertebrates
Biological Reviews, Volume 96, Issue 3, Page 1051-1075, June 2021., 2021 ABSTRACT Many aquatic invertebrates are associated with surfaces, using adhesives to attach to the substratum for locomotion, prey capture, reproduction, building or defence. Their intriguing and sophisticated biological glues have been the focus of study for decades.
Peter A. Davey +14 more
wiley +1 more source
Treatment of Radiation‐Induced Brain Necrosis
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Radiation‐induced brain necrosis (RBN) is a serious complication of intracranial as well as skull base tumors after radiotherapy. In the past, due to the lack of effective treatment, radiation brain necrosis was considered to be progressive and irreversible. With better understanding in histopathology and neuroimaging, the occurrence and development of
Xiaojing Yang +3 more
wiley +1 more source
Frontiers in Neuroscience, 2020 It remains a challenge for the effective treatment of neuroinflammatory disease, including multiple sclerosis (MS), stroke, epilepsy, and Alzheimer’s and Parkinson’s disease.
Xiaoli Wang +12 more
doaj +1 more source
Toxins, 2021 Actinoporins (APs) are soluble pore-forming proteins secreted by sea anemones that experience conformational changes originating in pores in the membranes that can lead to cell death. The processes involved in the binding and pore-formation of members of
Carlos Alvarez +8 more
doaj +1 more source