Results 41 to 50 of about 20,141 (153)

Vector diagrams.

, 2023
Inverted Terminal Repeat (ITR), Cytomegalovirus Enhancer Element (CMV Enh), Chicken beta Actin Promoter (CB), Simian Virus 40 intron (SV40 Intron), Enhanced Green Fluorescent Protein (EGFP), Woodchuck Hepatitis Virus Posttranscriptional Regulatory ...
Mark R. Tanner (8928290), Michael W. Pennington (8928323), Marco De Giorgi (819870), Yuqing Wang (110531), William R. Lagor (15208410), Ayrea Hurley (15208404), Christine Beeton (292361), Rong-Chi Hu (15208407)   +7 more
core   +1 more source

Scorpion Peptides: Potential Use for New Drug Development

Journal of Toxicology, Volume 2013, Issue 1, 2013., 2013
Several peptides contained in scorpion fluids showed diverse array of biological activities with high specificities to their targeted sites. Many investigations outlined their potent effects against microbes and showed their potential to modulate various biological mechanisms that are involved in immune, nervous, cardiovascular, and neoplastic diseases.
BenNasr Hmed, Hammami Turky Serria, Zeghal Khaled Mounir, Robert Tanguay   +3 more
wiley   +1 more source

Magnificamide, a β-Defensin-Like Peptide from the Mucus of the Sea Anemone Heteractis magnifica, Is a Strong Inhibitor of Mammalian α-Amylases

Marine Drugs, 2019
Sea anemones’ venom is rich in peptides acting on different biological targets, mainly on cytoplasmic membranes and ion channels. These animals are also a source of pancreatic α-amylase inhibitors, which have the ability to control the glucose
Oksana Sintsova, Irina Gladkikh, Aleksandr Kalinovskii, Elena Zelepuga, Margarita Monastyrnaya, Natalia Kim, Lyudmila Shevchenko, Steve Peigneur, Jan Tytgat, Emma Kozlovskaya, Elena Leychenko   +10 more
doaj   +1 more source

The Effect of Cholesterol on the Long-Range Network of Interactions Established among Sea Anemone Sticholysin II Residues at the Water-Membrane Interface

Marine Drugs, 2015
Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members.
Sara García-Linares, Ida Alm, Terhi Maula, José G. Gavilanes, Johan Peter Slotte, Álvaro Martínez-del-Pozo   +5 more
doaj   +1 more source

Amino acid sequences of ShK, its synthetic analog ShK-186, and its recombinant analog ShK-235.

, 2023
Differences between sequences are shown in bold and red. ShK is the 37 amino acid peptide originally isolated from the venom of the sea anemone Stichodactyla helianthus [22].
Mark R. Tanner (8928290), Michael W. Pennington (8928323), Marco De Giorgi (819870), Yuqing Wang (110531), William R. Lagor (15208410), Ayrea Hurley (15208404), Christine Beeton (292361), Rong-Chi Hu (15208407)   +7 more
core   +1 more source

The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels

Toxins, 2016
The bovine pancreatic trypsin inhibitor (BPTI)-Kunitz-type protein ShPI-1 (UniProt: P31713) is the major protease inhibitor from the sea anemone Stichodactyla helianthus.
Rossana García-Fernández, Steve Peigneur, Tirso Pons, Carlos Alvarez, Lidice González, María A. Chávez, Jan Tytgat   +6 more
doaj   +1 more source

1H, 13C, and 15N NMR assignments of StnII-Y111N, a highly impaired mutant of the sea anemone actinoporin Sticholysin II

, 2021
Sticholysin II is an actinoporin of 175 amino acids produced by the sea anemone Stichodactyla helianthus. Several studies with different mutants have been performed to characterize its molecular properties and activity.
Pardo-Cea, Miguel A., Martínez-del-Pozo, Álvaro, Bruix Bayés, Marta, Gavilanes, José G., Alegre-Cebollada, Jorge   +4 more
core   +1 more source

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

Marine Drugs, 2015
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM.
Michael W. Pennington, Shih Chieh Chang, Satendra Chauhan, Redwan Huq, Rajeev B. Tajhya, Sandeep Chhabra, Raymond S. Norton, Christine Beeton   +7 more
doaj   +1 more source

Structure–function relationships in ShKT domain peptides: ShKT‐Ts1 from the sea anemone Telmatactis stephensoni

Proteins: Structure, Function, and Bioinformatics, Volume 92, Issue 2, Page 192-205, February 2024.
Abstract Diverse structural scaffolds have been described in peptides from sea anemones, with the ShKT domain being a common scaffold first identified in ShK toxin from Stichodactyla helianthus. ShK is a potent blocker of voltage‐gated potassium channels (KV1.x), and an analog, ShK‐186 (dalazatide), has completed Phase 1 clinical trials in plaque ...
Karoline Sanches, Lauren M. Ashwood, Abisola Ave‐Maria Olushola‐Siedoks, Dorothy C. C. Wai, Arfatur Rahman, Kashmala Shakeel, Muhammad Umair Naseem, Gyorgy Panyi, Peter J. Prentis, Raymond S. Norton   +9 more
wiley   +1 more source

Role of the Tryptophan Residues in the Specific Interaction of the Sea Anemone Stichodactyla helianthus’s Actinoporin Sticholysin II with Biological Membranes

, 2016
Actinoporins are pore-forming toxins from sea anemones. Upon interaction with sphingomyelin-containing bilayers, they become integral oligomeric membrane structures that form a pore.
Esperanza Rivera-de-Torre (3340794), Álvaro Martínez-del-Pozo (1832395), Sara García-Linares (2574484), José G. Gavilanes (1832392), J. Peter Slotte (337797), Terhi Maula (3340797)   +5 more
core   +1 more source