Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. [PDF]
PLoS ONE, 2023 Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3 ...
Yuqing Wang +7 more
doaj +4 more sources
Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans [PDF]
Molecules and Cells: Organismal survival depends on coordinated responses to oxidative stress and DNA damage. Using Caenorhabditis elegans, we investigate mul-1, a robust transcriptional target of ionizing radiation and reactive oxygen species.
Emilio Carranza-García +3 more
doaj +2 more sources
Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family [PDF]
BMC Biology, 2023 Background The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in Actiniarians remain uncharacterised. One such peptide family, sea anemone 8 (SA8),
Lauren M. Ashwood +22 more
doaj +2 more sources
Structure of the recombinant BPTI/Kunitz-type inhibitorrShPI-1A from the marine invertebrateStichodactyla helianthus [PDF]
Acta Crystallographica Section F: Structural Biology Communications, 2012 Markus Perbandt +2 more
exaly +2 more sources
Effects of Lipid Composition on Membrane Permeabilization by Sticholysin I and II, Two Cytolysins of the Sea Anemone Stichodactyla helianthus [PDF]
Biophysical Journal, 2001 Cristina Potrich +2 more
exaly +2 more sources
Sticholysin I–II oligomerization in the absence of membranes
FEBS Letters, Volume 596, Issue 8, Page 1029-1036, April 2022., 2022 In this study, the oligomerization in solution of StnI and StnII, two pore‐forming toxins produced by Stichodactyla helianthus, has been studied using analytical ultracentrifugation. Our results show that while StnI is more prone to oligomerize than StnII when assayed independently, the addition of a small amount of StnII favours oligomerization ...
Sara García‐Linares +8 more
wiley +1 more source
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges
Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021 Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič +9 more
wiley +1 more source
Omics‐based molecular analyses of adhesion by aquatic invertebrates
Biological Reviews, Volume 96, Issue 3, Page 1051-1075, June 2021., 2021 ABSTRACT Many aquatic invertebrates are associated with surfaces, using adhesives to attach to the substratum for locomotion, prey capture, reproduction, building or defence. Their intriguing and sophisticated biological glues have been the focus of study for decades.
Peter A. Davey +14 more
wiley +1 more source
Treatment of Radiation‐Induced Brain Necrosis
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Radiation‐induced brain necrosis (RBN) is a serious complication of intracranial as well as skull base tumors after radiotherapy. In the past, due to the lack of effective treatment, radiation brain necrosis was considered to be progressive and irreversible. With better understanding in histopathology and neuroimaging, the occurrence and development of
Xiaojing Yang +3 more
wiley +1 more source
Frontiers in Neuroscience, 2020 It remains a challenge for the effective treatment of neuroinflammatory disease, including multiple sclerosis (MS), stroke, epilepsy, and Alzheimer’s and Parkinson’s disease.
Xiaoli Wang +12 more
doaj +1 more source