Results 1 to 10 of about 13,996 (89)
PLoS ONE, 2023 Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3 ...
Yuqing Wang +7 more
doaj +3 more sources
Sticholysin I–II oligomerization in the absence of membranes
FEBS Letters, Volume 596, Issue 8, Page 1029-1036, April 2022., 2022 In this study, the oligomerization in solution of StnI and StnII, two pore‐forming toxins produced by Stichodactyla helianthus, has been studied using analytical ultracentrifugation. Our results show that while StnI is more prone to oligomerize than StnII when assayed independently, the addition of a small amount of StnII favours oligomerization ...
Sara García‐Linares +8 more
wiley +1 more source
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges
Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021 Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič +9 more
wiley +1 more source
Omics‐based molecular analyses of adhesion by aquatic invertebrates
Biological Reviews, Volume 96, Issue 3, Page 1051-1075, June 2021., 2021 ABSTRACT Many aquatic invertebrates are associated with surfaces, using adhesives to attach to the substratum for locomotion, prey capture, reproduction, building or defence. Their intriguing and sophisticated biological glues have been the focus of study for decades.
Peter A. Davey +14 more
wiley +1 more source
Treatment of Radiation‐Induced Brain Necrosis
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Radiation‐induced brain necrosis (RBN) is a serious complication of intracranial as well as skull base tumors after radiotherapy. In the past, due to the lack of effective treatment, radiation brain necrosis was considered to be progressive and irreversible. With better understanding in histopathology and neuroimaging, the occurrence and development of
Xiaojing Yang +3 more
wiley +1 more source
Frontiers in Neuroscience, 2020 It remains a challenge for the effective treatment of neuroinflammatory disease, including multiple sclerosis (MS), stroke, epilepsy, and Alzheimer’s and Parkinson’s disease.
Xiaoli Wang +12 more
doaj +1 more source
Toxins, 2021 Actinoporins (APs) are soluble pore-forming proteins secreted by sea anemones that experience conformational changes originating in pores in the membranes that can lead to cell death. The processes involved in the binding and pore-formation of members of
Carlos Alvarez +8 more
doaj +1 more source
Determination of the boundary lipids of sticholysins using tryptophan quenching
Scientific Reports, 2022 Sticholysins are α-pore-forming toxins produced by the sea-anemone Stichodactyla helianthus. These toxins exert their activity by forming pores on sphingomyelin-containing membranes.
Juan Palacios-Ortega +7 more
doaj +1 more source
Ecology and Evolution, Volume 10, Issue 21, Page 12348-12363, November 2020., 2020 We investigated the abundance and gene expression of scavenger receptors and thrombospondin‐type‐1 repeat protein superfamily, known to be involved in symbiont recognition, in three plastid‐bearing sea slugs. We could identify candidate receptors, similar to those found in cnidarians for Symbiodinium recognition, that might be relevant in plastid ...
Jenny Melo Clavijo +6 more
wiley +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2018 Background Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities.
Cláudia S. Oliveira +13 more
doaj +1 more source