Results 21 to 30 of about 1,026 (176)
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges
Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021 Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič +9 more
wiley +1 more source
Omics‐based molecular analyses of adhesion by aquatic invertebrates
Biological Reviews, Volume 96, Issue 3, Page 1051-1075, June 2021., 2021 ABSTRACT Many aquatic invertebrates are associated with surfaces, using adhesives to attach to the substratum for locomotion, prey capture, reproduction, building or defence. Their intriguing and sophisticated biological glues have been the focus of study for decades.
Peter A. Davey +14 more
wiley +1 more source
Synergistic Action of Actinoporin Isoforms from the Same Sea Anemone Species Assembled into Functionally Active Heteropores [PDF]
, 2016 Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are the pore-forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes.
Alegre Cebollada, Jorge +5 more
core +5 more sources
Treatment of Radiation‐Induced Brain Necrosis
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Radiation‐induced brain necrosis (RBN) is a serious complication of intracranial as well as skull base tumors after radiotherapy. In the past, due to the lack of effective treatment, radiation brain necrosis was considered to be progressive and irreversible. With better understanding in histopathology and neuroimaging, the occurrence and development of
Xiaojing Yang +3 more
wiley +1 more source
Frontiers in Neuroscience, 2020 It remains a challenge for the effective treatment of neuroinflammatory disease, including multiple sclerosis (MS), stroke, epilepsy, and Alzheimer’s and Parkinson’s disease.
Xiaoli Wang +12 more
doaj +1 more source
Toxins, 2021 Actinoporins (APs) are soluble pore-forming proteins secreted by sea anemones that experience conformational changes originating in pores in the membranes that can lead to cell death. The processes involved in the binding and pore-formation of members of
Carlos Alvarez +8 more
doaj +1 more source
Determination of the boundary lipids of sticholysins using tryptophan quenching
Scientific Reports, 2022 Sticholysins are α-pore-forming toxins produced by the sea-anemone Stichodactyla helianthus. These toxins exert their activity by forming pores on sphingomyelin-containing membranes.
Juan Palacios-Ortega +7 more
doaj +1 more source
Ecology and Evolution, Volume 10, Issue 21, Page 12348-12363, November 2020., 2020 We investigated the abundance and gene expression of scavenger receptors and thrombospondin‐type‐1 repeat protein superfamily, known to be involved in symbiont recognition, in three plastid‐bearing sea slugs. We could identify candidate receptors, similar to those found in cnidarians for Symbiodinium recognition, that might be relevant in plastid ...
Jenny Melo Clavijo +6 more
wiley +1 more source
, 2015 An immobilized biocatalyst (ShIE-Octyl) was obtained by interfacial adsorption on Octyl-Sepharose CL 4B sup-port of all interfacial esterases from the aqueous extract of the sea anemone Stichodactyla helianthus. ShIE-Octyl, synthesized by this simple method, contains semipurified interfacial esterases, including the isotoxins StI and StII.
Alberto del Monte‐Martínez +8 more
openalex +3 more sources
Atypical reactive center Kunitz-type inhibitor from the sea anemone Heteractis crispa [PDF]
, 2012 The primary structure of a new Kunitz-type protease inhibitor InhVJ from the sea anemone Heteractis crispa (Radianthus macrodactylus) was determined by protein sequencing and cDNA cloning.
Anastyuk, S. +10 more
core +3 more sources