Results 21 to 30 of about 461 (139)

Pharmacological effects of two cytolysins isolated from the sea anemone Stichodactyla helianthus

Journal of Biosciences, 2009
Sticholysins I and II (St I/II) are cytolysins purified from the sea anemone Stichodactyla helianthus. In this study, we show their pharmacological action on guinea-pig and snail models in native and pH-denatured conditions in order to correlate the pharmacological findings with the pore-forming activity of both isoforms.
T, García, D, Martinez, A, Palmero, C, Soto, M, Tejuca, F, Pazos, R, Menéndez, C, Alvarez, A, Garateix   +8 more
openaire   +2 more sources

Screening and cDNA Cloning of Kv1 Potassium Channel Toxins in Sea Anemones

Marine Drugs, 2010
When 21 species of sea anemones were screened for Kv1 potassium channel toxins by competitive inhibition of the binding of 125I-α-dendrotoxin to rat synaptosomal membranes, 11 species (two species of Actiniidae, one species of Hormathiidae, five species ...
Kazuo Shiomi, Yuji Nagashima, Tomohiro Honma, Yuichi Hasegawa, Yoshikazu Yamaguchi   +4 more
doaj   +1 more source

Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

Toxins, 2018
Sea anemones have been understudied as a source of peptide and protein toxins, with relatively few examined as a source of new pharmacological tools or therapeutic leads. This is surprising given the success of some anemone peptides that have been tested,
Peter J. Prentis, Ana Pavasovic, Raymond S. Norton   +2 more
doaj   +1 more source

Peptide Fraction pOh2 Exerts Antiadipogenic Activity through Inhibition of C/EBP‐α and PPAR‐γ Expression in 3T3‐L1 Adipocytes

BioMed Research International, Volume 2017, Issue 1, 2017., 2017
Many studies have comprehensively examined the venom of Ophiophagus hannah snake. Its venom comprises different compounds exhibiting a wide range of pharmacological activities. In this investigation, four peptide fractions (PFs), ranging from 3 kDa to 10 kDa, isolated from the Vietnamese snake venom of O.
Thi Tuyet Nhung Nguyen, Thi Thu Ha, Thi Hoa Nguyen, Thi Hien Vu, Nam Hai Truong, Hoang Ha Chu, Dong Van Quyen, Gian L. Mariottini   +7 more
wiley   +1 more source

Partially Purified Extracts of Sea Anemone Anemonia viridis Affect the Growth and Viability of Selected Tumour Cell Lines

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis ...
Matteo Bulati, Alessandra Longo, Tiziana Masullo, Sara Vlah, Carmelo Bennici, Angela Bonura, Monica Salamone, Marcello Tagliavia, Aldo Nicosia, Salvatore Mazzola, Paolo Colombo, Angela Cuttitta, Michael Kalafatis   +12 more
wiley   +1 more source

Roles of Lymphocyte Kv1.3‐Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels

Mediators of Inflammation, Volume 2015, Issue 1, 2015., 2015
Delayed rectifier K+‐channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch‐clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo studies then revealed the clinically ...
Itsuro Kazama, Augusto Vaglio
wiley   +1 more source

Magnificamide, a β-Defensin-Like Peptide from the Mucus of the Sea Anemone Heteractis magnifica, Is a Strong Inhibitor of Mammalian α-Amylases

Marine Drugs, 2019
Sea anemones’ venom is rich in peptides acting on different biological targets, mainly on cytoplasmic membranes and ion channels. These animals are also a source of pancreatic α-amylase inhibitors, which have the ability to control the glucose
Oksana Sintsova, Irina Gladkikh, Aleksandr Kalinovskii, Elena Zelepuga, Margarita Monastyrnaya, Natalia Kim, Lyudmila Shevchenko, Steve Peigneur, Jan Tytgat, Emma Kozlovskaya, Elena Leychenko   +10 more
doaj   +1 more source

Structural and functional characterization of sticholysin III: A newly discovered actinoporin within the venom of the sea anemone Stichodactyla helianthus [PDF]

Archives of Biochemistry and Biophysics, 2020
Actinoporins are a family of pore-forming toxins produced by sea anemones as part of their venomous cocktail. These proteins remain soluble and stably folded in aqueous solution, but when interacting with sphingomyelin-containing lipid membranes, they become integral oligomeric membrane structures that form a pore permeable to cations, which leads to ...
Esperanza Rivera-de-Torre, Juan Palacios-Ortega, Jessica E. Garb, J. Peter Slotte, José G. Gavilanes, Álvaro Martínez-del-Pozo   +5 more
openaire   +3 more sources

Scorpion Peptides: Potential Use for New Drug Development

Journal of Toxicology, Volume 2013, Issue 1, 2013., 2013
Several peptides contained in scorpion fluids showed diverse array of biological activities with high specificities to their targeted sites. Many investigations outlined their potent effects against microbes and showed their potential to modulate various biological mechanisms that are involved in immune, nervous, cardiovascular, and neoplastic diseases.
BenNasr Hmed, Hammami Turky Serria, Zeghal Khaled Mounir, Robert Tanguay   +3 more
wiley   +1 more source

Extraction systems for isolating esterases having interfacial adsorption

Revista Colombiana de Biotecnología, 2009
Resumen: En el presente trabajo se optimizaron las condiciones de extracción de esterasas con actividad en interfaces, a partir de la anémona marina Stichodactyla helianthus y del camarón peneido Litopenaeus vannamei.
Alberto del Monte Martínez, Jorge González Bacerio, Lázara Romero del Sol, Carlos Aragón Abreu, Fernando Vega Villasante, Héctor Nolasco Soria, Joaquín Díaz Brito   +6 more
doaj   +2 more sources