Results 101 to 110 of about 31,428 (320)

Celebrities and Medical Awareness—The Case of Celine Dion and Stiff-Person Syndrome [PDF]

, 2023
Abdulrahman Elsalti, Mohammad Darkhabani, Mohamad Aosama Alrifaai, Naim Mahroum   +3 more
openalex   +1 more source

Application of a synthetic human proteome to autoantigen discovery through PhIP-Seq [PDF]

, 2014
In this study, we improve on current autoantigen discovery approaches by creating a synthetic representation of the complete human proteome, the T7 “peptidome” phage display library (T7-Pep), and use it to profile the autoantibody repertoires of ...
Church, George M., Ciccia, Alberto, Elledge, Stephen J., Gakidis, M. Angelica Martinez, Kesari, Santosh, Larman, H. Benjamin, Laserson, Uri, LeProust, Emily M., Li, Mamie Z., Solimini, Nicole L., Zhao, Zhenming   +10 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Stiff Person Syndrome: A Rare Presentation of a Rare Disorder

, 2023
Muhammad Hammad Sharif, Basil George Verghese   +1 more
openalex   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey [PDF]

, 2023
Naoko Matsui, Keiko Tanaka, Mitsuyo Ishida, Yohei Yamamoto, Yuri Matsubara, Reiko Saika, Takahiro Iizuka, Koshi Nakamura, Nagato Kuriyama, Makoto Matsui, Kokichi Arisawa, Yosikazu Nakamura, Ryuji Kaji, Satoshi Kuwabara, Yuishin Izumi, for the Japanese SPS Study   +15 more
openalex   +1 more source

Spartan Daily, March 2, 2009 [PDF]

, 2009
Volume 132, Issue 20https://scholarworks.sjsu.edu/spartandaily/10557/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Efficacy of Surgical Treatment for Thymoma-Related Stiff Person Syndrome

Annals of Thoracic Surgery Short Reports
Stiff person syndrome (SPS) is a neurologic disorder, some cases of which are associated with malignant disease. Here, we report a case of thymoma-associated SPS that was successfully treated with surgical resection.
Ryusuke Sumiya, MD, PhD, Takamitsu Banno, MD, Hiroyasu Ueno, MD, PhD, Shunki Hirayama, MD, PhD, Kenji Suzuki, MD, PhD   +4 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source