Results 81 to 90 of about 15,488 (268)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Stiff Person Syndrome and Myasthenia Gra

, 2002
Association of stiff person syndrome, an immune related disorder of anterior horn cells and myasthenia gravis an endplate disorder with similar pathogenesis, is rare.
P. K. Saravanan, J. Paul, Zaheer Ahmed Sayeed   +2 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Successful anesthetic management of patient with stiff person syndrome

, 2018
We herein describe the successful anesthetic management of a patient with stiff person syndrome undergoing right total hip replacement under spinal anesthesia. We also describe the problems associated with general anesthesia.
Siddiqui, Sarfraz, Sohaib, Muhammad
core  

Stiff-Person Syndrome [PDF]

, 2019
Stiff person syndrome spectrum disorder (SPSSD) consists of a rare set of diseases characterized by severe muscle stiffness and rigidity with decline in function. Although poorly understood, an underlying autoimmune disorder interfering with the CNS inhibitory mechanism is likely the culprit.
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

PET evidence of central GABAergic changes in stiff-person syndrome

, 2007
We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS).
V. Garibotto, Corbo, Massimo, D. Perani, A. Panzacchi, M. Corbo, R. M. Moresco, Ortelli, Paola, F. Folli, PERANI, DANIELA FELICITA L., Garibotto, Valentina, Fazio, Ferruccio, P. Ortelli, Panzacchi, Andrea, F. Fazio, Moresco Rosa Maria,, Folli, Franco   +15 more
core   +1 more source

Efficacy of Surgical Treatment for Thymoma-Related Stiff Person Syndrome

Annals of Thoracic Surgery Short Reports
Stiff person syndrome (SPS) is a neurologic disorder, some cases of which are associated with malignant disease. Here, we report a case of thymoma-associated SPS that was successfully treated with surgical resection.
Ryusuke Sumiya, MD, PhD, Takamitsu Banno, MD, Hiroyasu Ueno, MD, PhD, Shunki Hirayama, MD, PhD, Kenji Suzuki, MD, PhD   +4 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Lower Extremity Predominant Stiff-Person Syndrome and Limbic Encephalitis With Amphiphysin Antibodies in Breast Cancer

, 2012
A 54-year-old woman presented with several weeks of psychiatric symptoms, partial-onset seizures, and painful spasms of the lower extremities. On examination, she exhibited severe stiffness and intermittent extensor spasms of the lower extremities ...
Sivakumar, Kumaraswamy, Knievel, Kerry, Krishna, Vivek R., Ladha, Shafeeq S.   +3 more
core   +1 more source