Results 81 to 90 of about 31,428 (320)

Editor's choice : European Society for Vascular Surgery (ESVS) 2020 clinical practice guidelines on the management of acute limb ischaemia

, 2020
A
Acosta, Stefan, Azuma, Nobuyoshi, Bastos Gonçalves, Frederico, Björck, Martin, Boyle, Jonathan R., Chakfé, Nabil, Choke, Edward T. C., Cochennec, Frederic, Cohnert, Tina U., de Borst, Gert J., Document Reviewers, Earnshaw, Jonothan J., ESVS Guidelines Committee, Fitridge, Robert A., Forbes, Thomas L., Hamady, Mohamad S., Hinchliffe, Robert, Jongkind, Vincent, Kakkos, Stavros K., Koelemay, Mark J. W., Koncar, Igor, Lindholt, Jes S., Mani, Kevin, Menyhei, Gabor, Munoz, Alberto, Müller-Hülsbeck, Stefan, Rai, Kumud, Sebastian Debus, E., Svetlikov, Alexei V., Tshomba, Yamume, Tulamo, Riikka, van den Berg, Jos C., Vega de Ceniga, Melina, Vermassen, Frank   +33 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Efgartigimod beyond myasthenia gravis: the role of FcRn-targeting therapies in stiff-person syndrome [PDF]

, 2023
Vincenzo Di Stefano, Paolo Alonge, Nicasio Rini, Massimiliano Militello, Antonino Lupica, A de Torrenté, Filippo Brighina   +6 more
openalex   +1 more source

The Psychosocial Effects of the Li-Fraumeni Education and Early Detection (LEAD) Program on Indivdiuals with Li-Fraumeni Syndrome [PDF]

, 2016
Li-Fraumeni syndrome (LFS) is a hereditary cancer syndrome that leads to an increased risk of multiple cancers. In the past five years new screening protocols have been developed that provide improved screening options for individuals with LFS.
Ross, Jessica L
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stiff Person Syndrome Misdiagnosed as Oxaliplatin Induced Neurotoxicity [PDF]

, 2021
K A Shaima, D Meghana, K Rooha, Cipher Oncology Private Limited, Telangana, Hyderabad - 500096, India, Sarita J   +4 more
openalex   +1 more source

The pectoralis minor muscle and shoulder movement-related impairments and pain: Rationale, assessment and management [PDF]

, 2016
The adaptive shortening or tightness of the pectoralis minor muscle (PMm) is one of the potential biomechanical mechanisms associated with altered scapular alignment at rest and scapular motion during arm elevation (scapular dyskinesis) in patients with ...
Cruz, Joana, Morais, Nuno
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Stiff-person Syndrome with Cerebellar Manifestations and Foot Deformities

International Journal of Gerontology, 2013
Stiff-person syndrome (SPS) is a disabling disorder of the central nervous system that is characterized by episodic rigidity and spasticity. We report the case of a woman who had SPS with cerebellar manifestations (SPS-Cer) and asymmetric deformed feet ...
Cheng-I Chu, I-Hung Hsueh, Shih-Jung Cheng   +2 more
doaj   +1 more source