Results 101 to 110 of about 2,297,727 (227)

Finite element multistep multideriavative schemes for parabolic equations [PDF]

, 1976
The linear, homogeneous, parabolic equation is solved by applying finite element discretizations in space and A0 —stable, linear multistep, multiderivative (L.M.S.D.) methods in time. Such schemes are unconditionally stable. An error analysis establishes
Moore, P
core   +2 more sources

High order boundary value linear multistep method for the numerical solution of IVPs in ODEs

Journal of Nigerian Society of Physical Sciences
In this paper, we introduce High order boundary value linear multistep method (HOBVLMM) for the numerical solution of stiff systems of initial value problems (IVPs).
Seun Ogunfeyitimi, Monday Ikhile, Peter Olatunji   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On the Loss of L-stability of the Implicit Euler Method for a Linear Problem

Известия Иркутского государственного университета: Серия "Математика", 2015
A number of important applied problems of chemical kinetics, biophysics, theory of electrical circuits are described by systems of stiff ordinary differential equations with given initial conditions.
M.V. Bulatov, L.S. Solovarova
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A ninth-order first derivative method for numerical integration

Journal of Nigerian Society of Physical Sciences
In this paper, we present a ninth–order block hybrid method for the numerical solution of stiff and non–stiff systems of first–order differential equations.
Richard Akinola, Ezekiel Omole, Joshua Sunday, Stephen Kutchin   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A 4-Stage Runge-Kutta Type Method for Solution of Stiff Ordinary Differential Equations

Pan-American Journal of Mathematics
In this paper, a 2 step implicit block hybrid linear multistep method was reformulated into a 4-stage block hybrid Runge-Kutta Type Method via the butcher analysis. The method can be used to solve first order stiff ordinary differential equations.
Raihanatu Muhammad, Abdulmalik Oyedeji
doaj   +1 more source