Results 81 to 90 of about 7,385 (298)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Numerical solutions of stiff ordinary differential equations and differential algebraic equations using one-step implicit hybrid methods [PDF]

open access: yes, 2015
The numerical solutions of stiff ordinary differential equations and differential algebraic equations have been studied in this thesis. New one-step implicit hybrid methods are developed to solve stiff ordinary differential equations (ODEs) and ...
Khoo, Kai Wen
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Stiff differential equations solved by Radau methods

open access: yes, 1999
Radau IIA methods are successful algorithms for the numerical solution of stiff differential equations. This article describes RADAU, a new implementation of these methods with a variable order strategy.
Ernst Hairer   +3 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Stability regions for one-step multiderivative methods

open access: yes, 1981
Stability regions are plotted for certain members of a family of one-step multiderivative predictor-corrector methods developed by the authors in an earlier paper.
Khaliq, AQM, Twizell, EH
core  

Stability Analysis of Singly Diagonally Implicit Block Backward Differentiation Formulas for Stiff Ordinary Differential Equations

open access: yesMathematics, 2019
In this research, a singly diagonally implicit block backward differentiation formulas (SDIBBDF) for solving stiff ordinary differential equations (ODEs) is proposed.
Saufianim Jana Aksah   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Realtime Simulation of Detailed Vehicle and Powertrain Dynamics

open access: yes, 2004
This paper describes typical modeling and real-time simulation issues that occur in automotive applications. Real-time simulations of detailed Modelica benchmark models for chassis and powertrain are presented.
Johan Andreasson   +13 more
core   +1 more source

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