Results 91 to 100 of about 2,297,727 (227)
Kuwait Journal of Science, 2015 In this paper, Magnus Series Expansion Method which is based on Lie Groups and Lie algebras is proposed with different orders to solve nonhomogeneous stiff systems of ordinary differential equations.
Mehmet T. Atay +2 more
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Efficient PINNs via multi-head unimodular regularization of the solutions space
Communications PhysicsNon-linear differential equations are a fundamental tool to describe different phenomena in nature. However, we still lack a well-established method to tackle stiff differential equations.
Pedro Tarancón-Álvarez +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Recent Advances in Natural SciencesThis study introduces a novel one-step hybrid block method for solving both stiff and non-stiff second-order ordinary differential equations (ODEs).
Saidu Daudu Yakubu, Precious Sibanda
doaj +1 more source
(α)-Stable Multi-Derivative GLM
Journal of Algorithms & Computational Technology, 2015 This paper considers multi-derivative general linear methods and thus presents some second and third derivative general linear methods of orders 5, 7 and 10 in its output methods for computing the solution of stiff initial value problems in ordinary ...
R. I. Okuonghae, M. N. O. Ikhile
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Fifth-Order Block Hybrid Approach for Solving First-Order Stiff Ordinary Differential Equations
AppliedMathThis study introduces a novel single-step hybrid block method with three intra-step points that attains fifth-order accuracy, offering an accurate and computationally economical tool for solving first-order differential equations.
Ibrahim Mohammed Dibal, Yeak Su Hoe
doaj +1 more source
An Improved Block Backward Differentiation Formula for Stiff Differential Equations
In this work, we derived eight-order, implicit block formula using backward differentiation method with two off-step points for solving stiff ordinary differential equations. We solve some standard set of stiff initial value problems (IVPs) using the new method.
Abhulimen, C.E, Umar, M. A, Amuno, E. O.
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source