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, 2022 Background: Stiff-person syndrome is a disorder of the central nervous system that manifests by progressive rigidity together with muscle spasms of the axial and limb muscles. After its initial description in 1956, significant progress has been made in its diagnosis and treatment, although there are still unclear elements about its pathogenesis.
Simon, Florian,
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Expanding the Understanding of Stiff-Person Syndrome: Insights from 17 Cases in India
Annals of Indian Academy of NeurologyStiff-person syndrome (SPS) is a rare and complex neurologic disorder characterized by progressive muscle stiffness, painful spasms, and gait difficulties.
Rajendra S. Jain +3 more
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Stiff Person Syndrome and Gluten Sensitivity [PDF]
Nutrients, 2021 Stiff person syndrome (SPS) is a rare autoimmune disease characterised by axial stiffness and episodic painful spasms. It is associated with additional autoimmune diseases and cerebellar ataxia. Most patients with SPS have high levels of glutamic acid decarboxylase (GAD) antibodies.
Hadjivassiliou, M. +4 more
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Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1992 ABSTRACT:The stiff-person syndrome is a disorder of persistent, painful muscle contractions predominately affecting the axial musculature. We describe a patient with this disorder and review its pathophysiology. Molecular biologic and immunologic techniques have recently added to the understanding of the mechanism of this disorder.
M S, Jog, C D, Lambert, A E, Lang
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, 2022 Pituitary adenoma can manifest as pituitary hypofunction, which can cause symptoms of panhypopituitarism. Commonly, symptoms of hormonal deficiencies such as lethargy, weight change, cold intolerance, and sexual dysfunction are reported.
Goh, Kian Guan +2 more
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Stiff Person Syndrome and Acetylcholine Receptor Ganglionic Neuronal Antibodies
Case Reports in Neurology, 2020 The association between stiff person syndrome and paraneoplastic syndromes has been described, linking intracellular or extracellular antibodies. We describe the case of a 64-year-old woman with stiff person syndrome and positivity for acetylcholine ...
Jacobo Lester +2 more
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Frontiers in Neurology, 2023 BackgroundStiff Person Syndrome Spectrum Disorders (SPSD) are a group of rare neurological disorders that can present alongside other autoimmune conditions.
Alexandra Balshi +9 more
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Stiff-person syndrome – a literature review
Aktualności Neurologiczne, 2019 Stiff-person syndrome, also known as stiff-man syndrome (SMS) or the Moersch–Woltman syndrome, was first described in 1956. The disease is rare. The estimated prevalence in the general population is 1–2 cases/1,000,000, and the annual incidence is 1 case
Karol Jastrzębski
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Brain Sciences, 2023 Antibodies to glutamic acid decarboxylase (GAD) have been predominantly associated with stiff-person syndrome (SPS), which is often accompanied by organ-specific autoimmune diseases, such as late-onset type 1 diabetes. Autoimmune retinal pathology in SPS
Vassilis E. Papadopoulos +4 more
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Stiff Person Syndrome Associated with Compartment Syndrome
Case Reports in Neurology, 2019 Stiff person syndrome (SPS) is a rare and disabling neurological disorder of autoimmune origin, characterized by progressive stiffness and muscle spasms affecting the axial and limb muscles, most frequently associated with antibodies against glutamic ...
Kok Pin Yong, Yew Long Lo
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