Results 71 to 80 of about 124,061 (401)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Stifle kinematics in 4 dogs with cranial cruciate ligament insufficiency treated by CORA-based leveling osteotomy

Frontiers in Veterinary Science, 2022
ObjectiveThe purpose of this study was to quantify three-dimensional (3D) stifle kinematics during walking in dogs with complete cranial cruciate ligament insufficiency (CCL-I) treated with a CORA-based leveling osteotomy (CBLO).Study designFour client ...
Selena Tinga, Natalie Hughes, Stephen C. Jones, Brian Park, Lindsey Palm, Sasank S. Desaraju, Scott A. Banks, Sandra L. MacArthur, Daniel D. Lewis   +8 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

On viscosity, conduction and sound waves in the intracluster medium

, 2005
Recent X-ray and optical observations of the Perseus cluster indicate that the viscous and conductive dissipation of sound waves is the mechanism responsible for heating the intracluster medium and thus balancing radiative cooling of cluster cores.
A. C. Fabian, Bauer, Benson, Binney, Birzan, Blanton, Blanton, Braginskii, Böhringer, C. S. Reynolds, Carilli, Churazov, Churazov, Conselice, Crawford, Dunn, Edge, Fabian, Fabian, Fabian, Fabian, Fabian, Fujita, Fujita, G. B. Taylor, Heinz, Inogamov, Johnstone, Kaastra, Landau, Longcope, Lynds, McNamara, McNamara, Narayan, Navarro, Nulsen, Nulsen, Peres, Pringle, R. J. H. Dunn, Reynolds, Reynolds, Ruszkowski, Ruszkowski, Sanders, Spitzer, Stein, Taylor, Tozzi, Vogt, Voigt, Wilson, Zensus   +53 more
core   +4 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Peri-articular histiocytic sarcoma and synovial cell sarcoma in Bernese Mountain dogs : a retrospective investigation of the prevalence of these tumours in association with previously diseased joints [PDF]

, 2010
C
Brearley, Malcolm, Butinar, Janos, Chiers, Koen, de Vos, Johan, Gielen, Ingrid, Maes, Sofie, Van Garderen, Evert, van Ginkel, Kostijn, Van Kuijk, Lotte, Verhoeven, Nel   +9 more
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Follow the Crowd in a New Direction: When Conformity Pressure Facilitates Group Creativity (And When It Does Not) [PDF]

, 2011
Adopting a person by situation interaction approach, we identified conditions under which conformity pressure can either stifle or boost group creativity depending on the joint effects of norm content and group personality composition.
Duguid, Michelle M, Goncalo, Jack
core   +1 more source

Ex vivo biomechanical investigations of combined extra- and intracapsular stabilization in canines with cranial cruciate ligament deficiency

Frontiers in Veterinary Science
Intracapsular reconstruction (ICR) has long been recommended as a treatment for cranial cruciate ligament deficiency (CCLD) in dogs, but it has fallen out of favor due to its inferior long-term functional outcomes. These outcomes may be attributed to the
Cheng-Yuan Sun, Cheng-Chung Lin, Ching-Ho Wu   +2 more
doaj   +1 more source