Results 11 to 20 of about 942 (180)

New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3H)-benzothiazolones

open access: yesPharmaceuticals, 2021
Here, we describe the synthesis, characterization, and biological activities of a series of 26 new styryl-2(3H)-benzothiazolone analogs of combretastatin-A4 (CA-4).
Gjorgji Atanasov   +7 more
doaj   +1 more source

SK-03-92 Drug Kills Intracellular Mycobacterium tuberculosis

open access: yesAntibiotics, 2023
Background: Tuberculosis affects millions of people worldwide. The emergence of drug-resistant Mycobacterium tuberculosis strains has made treatment more difficult.
William R. Schwan
doaj   +1 more source

Control of stilbene conformation and fluorescence in self-assembled capsules

open access: yesBeilstein Journal of Organic Chemistry, 2009
The extensively studied trans-stilbene molecule is known to give only weak fluorescence in solution and inside loosely-fitting synthetic capsules. However, trans-stilbene has been recently studied in the context of antibody interiors, where binding ...
Mark R. Ams   +4 more
doaj   +1 more source

Fate of Antioxidative Compounds within Bark during Storage: A Case of Norway Spruce Logs

open access: yesMolecules, 2020
Softwood bark is an important by-product of forest industry. Currently, bark is under-utilized and mainly directed for energy production, although it can be extracted with hot water to obtain compounds for value-added use.
Tuula Jyske   +9 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol

open access: yesPharmaceuticals, 2021
A library of sulfonate and sulfonamide derivatives of Resveratrol was synthesized and tested for its aromatase inhibitory potential. Interestingly, sulfonate derivatives were found to be more active than sulfonamide bioisosteres with IC50 values in the ...
Marialuigia Fantacuzzi   +12 more
doaj   +1 more source

Cytotoxicity and genotoxicity of stilbene derivatives in CHO-K1 and HepG2 cell lines

open access: yesGenetics and Molecular Biology, 2017
The cytotoxicity and genotoxicity of the stilbenes (E)-methyl-4-(3-5-dimethoxystyryl)benzoate (ester), (E)-4-(3-5-dimethoxystyryl)aniline (amino), (Z)-1,3-dimethoxy-5-(4-methoxystyryl)benzene (cis-TMS) and (E)-1,3-dimethoxy-5-(4-methoxystyryl)benzene ...
Cassia Suemi Mizuno   +6 more
doaj   +1 more source

Antiproliferative Effects in Colorectal Cancer and Stabilisation in Cyclodextrins of the Phytoalexin Isorhapontigenin

open access: yesBiomedicines, 2023
Isorhapontigenin has been proposed as a better alternative for oral administration than the famous resveratrol, as it shares many biological activities, but with a structure that could make its delivery easier.
Silvia Navarro-Orcajada   +5 more
doaj   +1 more source

Switching behaviour of stilbene molecular device: a first-principles study

open access: yesCondensed Matter Physics, 2018
The switching behaviour of stilbene molecular system (SMS) device is investigated with the help of non-equilibrium Green’s function (NEGF) approach using first principles calculation. The transmission spectrum of cis-isomers confirmed that more electrons
V. Nagarajan, R. Chandiramouli
doaj   +1 more source

Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray

open access: yesAntibiotics, 2017
The mechanism of action for a new lead stilbene compound coded SK-03-92 with bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) is unknown. To gain insight into the killing process, transcriptional profiling was performed on
William R. Schwan   +14 more
doaj   +1 more source

Bioactive natural products from orchids native to the Americas - A review

open access: yesAnais da Academia Brasileira de Ciências, 2023
The purpose of this review is to provide information on the traditional uses, phytochemical and pharmacological studies performed with species of orchids native to the Americas and the Caribbean Islands.
ARMANDO MATEUS POMINI   +3 more
doaj   +1 more source

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