Results 71 to 80 of about 4,864,129 (252)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Adult-onset Still’s disease: pathogenesis, symptoms, diagnostics and treatment. [PDF]

, 2021
Adult-onset Still’s disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. Typically this disease occurs by four main symptoms: spiking fever ≥ 39 °C, arthralgia or arthritis, skin rash, and leukocytosis (≥ 10 ...
Kaušaitė, Dominyka,
core  

Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?

, 2021
Still’s disease and Kawasaki disease (KD) today belong to the group of cytokine storm syndromes, a pathophysiological set related to excessive activation of the innate immune response. We present here a personal vision of what can link these two diseases,
Perrine Dusser, Isabelle Koné-Paut
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Difficulties in diagnosis and treatment of adult-onset Still's disease concurrent with pericardial effusion as a leading clinical manifestation

Современная ревматология, 2016
The paper considers a case of adult-onset Still's disease that occurred as acute pericarditis, two-spike hectic fever, and neutrophilic leukocytosis in a young man.
V. Yu. Myachikova, A. L. Maslyansky, I. Z. Gaydukova, A. N. Novikova, D. V. Karpova, E. V. Shlyakhto   +5 more
doaj   +1 more source

Still’s disease in adults

Мета роботи – на прикладі клінічного випадку ознайомити лікарів з особливостями клінічного перебігу хвороби Стілла. Наведено витяг з історії хвороби пацієнтки, госпіталізованої в інфекційне відділення ОКНП «Чернівецька обласна клінічна лікарня», в якої ...
Сhernetska, N.V., Баланюк, Ірина Володимирівна, Москалюк, Василь Деонізійович, Меленко, Світлана Романівна, Чернецька, Наталія Василівна, Кравчук, І.І., Melenko, S.R., Kravchuk, I.I., Kostina, N.V., Костіна, Н.В., Balaniuk, I.V., Moskaliuk, V.D.   +11 more
core   +1 more source

Mixed results with baricitinib in biological-resistant adult-onset Still’s disease and undifferentiated systemic autoinflammatory disease [PDF]

, 2020
This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still’s disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory ...
Fitton, J, Savic, S, Buch, MH, Kacar, M, McGonagle, DG, Gough, AK   +5 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Still’s Disease Across Ages

Still’s disease has long been divided by age at onset into systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD). The 2024 evidence synthesis prepared for the European Alliance of Associations for Rheumatology/Pediatric ...
Ivica Jeremić
core   +1 more source

EULAR/PReS recommendations for the diagnosis and management of Still’s disease, comprising systemic juvenile idiopathic arthritis and adult-onset Still’s disease [PDF]

Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are considered the same disease, but a common approach for diagnosis and management is still missing.
Feist, Eugen, Quartier, Pierre, Truchetet, Marie-Elise, Belot, Alexandre, Wouters, C., Lazar, C., Tamàs Constantin, Alexandre Belot, Sophie Georgin-Lavialle, Antón, Jordi, Ozen, S., Erdal Sag, Dagna, Lorenzo, Loreto Carmona, Carmona, L., Mitrovic, Stéphane, Fautrel, B., Roberto Giacomelli, Bracaglia, C., Antón, J., Marie-Elise Truchetet, Wilhelmer, T.-C., Nigrovic, Peter, Di Bartolo, Alessandro, Jordi Antón, Arianna De Matteis, Sag, Erdal, De Benedetti, F., Fabrizio De Benedetti, Foell, Dirk, Grom, Alexei, Sara Bindoli, Carine Wouters, Feist, E., Filipa Oliveira Ramos, Giacomelli, R., Ruscitti, Piero, Piero Ruscitti, Francesca Minoia, Ruscitti, P., Katerina Laskari, De Matteis, A., Peter A Nigrovic, Nigrovic, P.A., Grom, Alexei A, Foell, D., Sinisa Savic, Truchetet, M.-E., Grom, Alexei A., Lazar, Calin, Ozen, Seza, Eugen Feist, Marco Gattorno, Gattorno, M., Stéphane Mitrovic, Quartier, P., Carmona, Loreto, de Matteis, Arianna, Vastert, S.J., Giacomelli, Roberto, Minoia, F., Dirk Foell, Calin Lazar, Bracaglia, Claudia, Tanita-Christina Wilhelmer, Wouters, Carine, Oliveira Ramos, Filipa, Constantin, T., Dagna, L., Bindoli, Sara, Bindoli, S., Constantin, Tamàs, Claudia Bracaglia, Alessandro Di Bartolo, Seza Ozen, de Bartolo, A., Yvan Jamilloux, Di Bartolo, A., Grom, A.A., Savic, S., Vastert, Sebastiaan J., Nigrovic, Peter A., Lorenzo Dagna, Fautrel, Bruno, Jamilloux, Yvan, Vastert, Sebastiaan, Laskari, Katerina, Sebastiaan J Vastert, Mitrovic, S., Gattorno, Marco, Sag, E., Jamilloux, Y., de Benedetti, Fabrizio, Georgin-Lavialle, S., Pierre Quartier, Bruno Fautrel, Georgin-Lavialle, Sophie, Savic, Sinisa, Belot, A., Wilhelmer, Tanita-Christina, Minoia, Francesca, Alexei A Grom, Laskari, K., Vastert, Sebastiaan J, Nigrovic, Peter A, Ramos, F.O.   +105 more
core   +1 more source