Nox1-Derived ROS Amplifies Calcium Entry and Enhances Pneumolysin-Induced Lung Endothelial Barrier Dysfunction in Hyperglycemia. [PDF]
Antioxidants (Basel)Haigh S +21 more
europepmc +1 more source
Cardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress [Retraction]. [PDF]
J Inflamm Reseuropepmc +1 more source
ATP depletion induces translocation of STIM1 to puncta and formation of STIM1–ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP [PDF]
Pflugers Archiv European Journal of Physiology, 2008 Depletion of the endoplasmic reticulum (ER) calcium store triggers translocation of stromal interacting molecule one (STIM1) to the sub-plasmalemmal region and formation of puncta-structures in which STIM1 interacts and activates calcium channels.
Ole Petersen +2 more
exaly +7 more sources
Mutations of the Ca2+-sensing Stromal Interaction Molecule STIM1 Regulate Ca2+ Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca2+ Channel Orai1 [PDF]
Journal of Biological Chemistry, 2013 A drop of endoplasmic reticulum Ca²⁺ concentration triggers its Ca²⁺ ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize and accumulate within endoplasmic reticulum-plasma membrane junctions where it activates Orai1 channels, providing ...
Grigori Rychkov +2 more
exaly +3 more sources
Role of the STIM1 C-terminal Domain in STIM1 Clustering [PDF]
Journal of Biological Chemistry, 2011 Store-operated Ca(2+) entry (SOCE) represents a ubiquitous Ca(2+) influx pathway activated by the filling state of intracellular Ca(2+) stores. SOCE is mediated by coupling of STIM1, the endoplasmic reticulum Ca(2+) sensor, to the Orai1 channel. SOCE inactivates during meiosis, partly because of the inability of STIM1 to cluster in response to store ...
Khaled Machaca, Raphaël Courjaret
exaly +3 more sources
TRPC channels as STIM1-regulated store-operated channels
Cell Calcium, 2007 Receptor-activated Ca2+ influx is mediated largely by store-operated channels (SOCs). TRPC channels mediate a significant portion of the receptor-activated Ca2+ influx.
Min Goo Lee, Guo N Huang, Paul Worley
exaly +2 more sources
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs [PDF]
FEBS Letters, 2010 Ca2+ entering cells through store-operated channels (SOCs) affects most cell functions, and excess SOC is associated with pathologies. The molecular makeup of SOCs and their mechanisms of gating were clarified with the discovery of the Orais and STIM1 ...
Paul Worley +2 more
exaly +2 more sources
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An increase in the intracellular calcium ion concentration ([Ca(2+)]) impacts a diverse range of cell functions, including adhesion, motility, gene expression and proliferation. Elevation of intracellular calcium ion (Ca(2+)) regulates various cellular events after the stimulation of cells.
Kurosaki, Tomohiro, Baba, Yasuhiko
openaire +3 more sources
STIM1 and Orai1 are the central core of the Store Operated Calcium Entry (SOCE). This calcium influx mechanism is triggered after the activation of Gq protein-coupled receptors at the plasma membrane (PM) that activate phospholipase C. The phospholipase C produces Inositol triphosphate (IP3) which rapidly diffuses throughout the cytosol, resulting in ...
Jonathan Pacheco +2 more
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STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets
Cellular Signalling, 2012Stromal interaction molecule 1 (STIM1) is a key element of the store-operated Ca(2+) entry mechanism (SOCE). Recently, regulation of STIM1 by glycosylation and phosphorylation on serine/threonine or proline residues has been described; however other modes of phosphorylation that are important for activating SOCE in platelets, such as tyrosine ...
Esther, Lopez +7 more
openaire +2 more sources