Results 191 to 200 of about 10,398 (215)
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STIM1 moonlights as an anchor for STING
Nature Immunology, 2019Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.
Jianjun Wu, Nan Yan
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2016
Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signalling pathway for a variety of cell functions, including T-cell activation as well as mast-cell degranulation. Depletion of [Ca(2+)]ER results in activation of Ca(2+) channels within the plasmamembrane that mediate sustained Ca(2+) influx which is ...
Irene, Frischauf +3 more
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Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signalling pathway for a variety of cell functions, including T-cell activation as well as mast-cell degranulation. Depletion of [Ca(2+)]ER results in activation of Ca(2+) channels within the plasmamembrane that mediate sustained Ca(2+) influx which is ...
Irene, Frischauf +3 more
openaire +2 more sources
The TRPCs–STIM1–Orai Interaction
2014Ca(2+) signaling entails receptor-stimulated Ca(2+) release from the ER stores that serves as a signal to activate Ca(2+) influx channels present at the plasma membrane, the store-operated Ca(2+) channels (SOCs). The two known SOCs are the Orai and TRPC channels.
Seok, Choi +7 more
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STIM1 Function in Mitosis and Meiosis
Qatar Foundation Annual Research Forum Proceedings, 2011Abstract The endoplasmic reticulum (ER) functions as a storehouse for intracellular Calcium. STIM1, a Calcium sensor localizes mostly to the ER membrane in interphase under resting conditions. Following Ca2+ store depletion, STIM1 forms puncta that localize to the cortical ER and binds Orai1, a Ca2+ channel to allow Ca2+ influx.
Rashmi Kulkarni +2 more
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Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade
Cellular and Molecular Life Sciences, 2021Heinrich Krobath +2 more
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Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
Biochemical and Biophysical Research Communications, 2006Pingyong Xu +2 more
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STIM1: a novel phosphoprotein located at the cell surface
BBA - Proteins and Proteomics, 2000Rick Pearson, Marie Dziadek
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