Results 61 to 70 of about 15,421,997 (282)

Sex differences in the characteristics of stimulant offenders with a history of substance use disorder treatment

Neuropsychopharmacology Reports, 2023
We analyzed the results of a nationwide questionnaire administered to 699 stimulant offenders and examined sex differences in the association between various psychosocial problems and treatment history for substance use disorder.
Ayumi Kondo, Takuya Shimane, Masaru Takahashi, Michiko Kobayashi, Marie Otomo, Yoshiko Takeshita, Toshihiko Matsumoto   +6 more
doaj   +1 more source

Psychosocial interventions in stimulant use disorders

Current Opinion in Psychiatry, 2017
Stimulant use disorders are significant contributors to the global burden of disease, with a growing impact on women. Psychosocial interventions are the gold standard for treating this condition, but several barriers may prevent women from accessing appropriate treatment. Therefore, we systematically reviewed the most recent findings about psychosocial
De Giorgi, R, D’Alò, G, De Crescenzo, F   +2 more
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Odds ratios for the association between having a cannabis use disorder and recent stimulant use.

, 2021
Odds ratios for the association between having a cannabis use disorder and recent stimulant use.
Bobby P. Smyth (11250348), Brian Galvin (7532831), Ivan J. Perry (7428053), Claire O’Dwyer (7532819), Seán R. Millar (11028077), Deirdre Mongan (7532822)   +5 more
core   +1 more source

Verbal memory dysfunction in substance use and gambling addictive disorders: a comparative analysis of performance accuracy and error typologies

Frontiers in Psychology
Addiction is increasingly recognized as a disorder involving not only reward dysregulation but also alterations in core cognitive processes, including learning and memory.
Davide Crivelli, Davide Crivelli, Doriana Losasso, Simona Riccardi, Maria Francesca Scaramuzzino, Gianmaria Zita, Michela Balconi, Michela Balconi   +7 more
doaj   +1 more source

The Autonomic Progress Bar Motivates Treatment Completion for Patients of Stimulant Use Disorder and Cannabis Use Disorder

Frontiers in Psychiatry, 2020
Background: The intrinsic motivation behind the “need to complete” is more influential than external incentives. We introduced a novel progress-bar tool to motivate the completion of programs designed to treat stimulant and cannabis use disorders.
I-Chun Chen, I-Chun Chen, Gloria Teng, Chur-Jen Chen, Tsuo-Hung Lan, Tsuo-Hung Lan, Hung-Jen Liu, Hung-Jen Liu   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source