Genome-wide analysis reveals ligand-dependent allostery in RARα:RXR-mediated transcriptional regulation. [PDF]
Cell RepHawkins CL, Blaner WS, Fernandez EJ.
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Faecalibacterium-derived spermidine mediates the amelioration of fatty liver hemorrhagic syndrome by inulin in laying hens. [PDF]
NPJ Biofilms MicrobiomesYang X, Li X, Xu D, Feng Y, Guo Y, Hu Y.
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Molecular Oncology, Volume 20, Issue 9, Page 2135-2162, September 2026.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
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Neuroprotective Role of E3 Ubiquitin Ligase TRIM2 in Parkinson's Disease: Attenuation of Oxidative Stress and Apoptosis via Promoting ELAVL1 Ubiquitination. [PDF]
CNS Neurosci TherLiang W, Sun W, Zhao Z, Song K, Jia J.
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Charting Morphotoxicity With Complementary Embryo Models
Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx +9 more
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All-trans retinoic acid suppresses CD8<sup>+</sup> T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma. [PDF]
Signal Transduct Target TherKang I +18 more
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Advanced Science, Volume 13, Issue 53, 24 September 2026.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
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Multi-omics and machine learning reveal LYZ and ISG15 as diagnostic and therapeutic targets in autoimmune-mediated chronic kidney disease. [PDF]
Front ImmunolZheng H +7 more
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Advanced Science, Volume 13, Issue 50, 7 September 2026.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source