Results 191 to 200 of about 61,886,207 (255)

A Stepwise Method to Derive Functional Pancreatic Islet‐like Clusters from Human Pluripotent Stem Cells

Current Protocols, Volume 6, Issue 9, September 2026.
Abstract The most common treatment for people with people with type 1 diabetes (T1D) requires injections of exogenous insulin to regulate blood glucose homeostasis. A longer‐term therapeutic solution for T1D has emerged whereby patients may regain insulin independence through transplantation of donated human pancreatic islets, which contain insulin ...
Manuj Bandral, Jimena Alvarez‐Castanon, David S. Lorberbaum   +2 more
wiley   +1 more source

Profiling Fecal Microbiome and Metabolites in a Feline Infectious Peritonitis Virus Challenge Model in Kittens: A Pilot Discovery Study. [PDF]

Int J Mol Sci
Zhen S, Yue H, Pan Y, Mu P, Zhang R, Wei J, Meng Z, Liu Y, Zhang J, Jiang L, Yu J, Yu X, Zhang X.   +12 more
europepmc   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Adapalene, an RAR agonist, exerts anti-inflammatory effects by regulating macrophage polarization through RAR[Formula: see text]-mediated signaling pathways. [PDF]

Sci Rep
Lee NH, Choi MJ, Ji SM, Kwak HJ, Cheon HG.   +4 more
europepmc   +1 more source

Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia, Chang Liang, Zhuoqing Zhuang, Pingrun Chen, Zhe Xiong, Junzhu Lu, Yan Zhang   +6 more
wiley   +1 more source

Interferon-alpha selectively signals mitochondrial pore opening to allow mitochondrial RNA release in systemic lupus erythematosus: pathophysiological implications. [PDF]

Cell Commun Signal
Huang CY, Wu DW, Hung LF, Wu CH, Luo SF, Ka SM, Chen A, Ho LJ, Lai JH.   +8 more
europepmc   +1 more source

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

Food Frontiers, Volume 7, Issue 5, September 2026.
Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi, Sally Kamau, Gulnaz Seitimova, Shynar Zhumagaliyeva, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +6 more
wiley   +1 more source

Phytocompounds That Target White Adipose Tissue for Weight Loss: A Review Spanning From Ucp1 Induction in Rodents to Human Clinical Trials. [PDF]

Obes Rev
Coulter AA, Greenway FL, Ramanathan G, Hubbard JR, Rebello CJ.   +4 more
europepmc   +1 more source

Structural Characterization and UVB Irradiation Protective Effect of the Polysaccharide From Tremella fuciformis After Microbial Fermentation

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Tremella fuciformis is an edible mushroom rich in bioactive polysaccharides. In this study, T. fuciformis was extracted by citric acid under high temperature and high‐pressure (121°C, 0.1 MPa), followed by fermentation with Saccharomyces cerevisiae CH006 and Thermus thermophilus HB27.
Xin‐Yan He, Jun‐Qiao Wang, Yi‐Qi Lin, Sih‐Yu Chu, Wen‐Xin Wang, Xuan‐Han Xiao, Yu‐Ke Hou, Xiao‐Feng Qiu, Shao‐Ping Nie, Zhi‐Jiang Wang, Huan‐Yu Liu   +10 more
wiley   +1 more source

Focus on Mucosal-Associated Invariant T Cell Antigens Fueling Biliary Liver Injury. [PDF]

Cell Mol Gastroenterol Hepatol
Mürle JJ, Filipowicz Sinnreich M.
europepmc   +1 more source