Results 61 to 70 of about 314,124 (266)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Stimulated emission from hexagonal silicon-germanium nanowires

Communications Physics
Hexagonal crystal phase silicon-germanium (hex-SiGe) features efficient direct bandgap emission between 1.5 and 3.4 µm. For expanding its application potential, the key challenge is to demonstrate material gain for enabling a hex-SiGe semiconductor laser.
Marvin A. J. van Tilburg, Riccardo Farina, Victor T. van Lange, Wouter H. J. Peeters, Steffen Meder, Marvin M. Jansen, Marcel A. Verheijen, M. Vettori, Jonathan J. Finley, Erik. P. A. M. Bakkers, Jos. E. M. Haverkort   +10 more
doaj   +1 more source

Stimulated Emission from a single excited atom in a waveguide

, 2012
We study stimulated emission from an excited two-level atom coupled to a waveguide containing an incident single-photon pulse. We show that the strong photon correlation, as induced by the atom, plays a very important role in stimulated emission ...
A. Einstein, A. E. Siegman, B. E. A. Saleh, Eden Rephaeli, Shanhui Fan   +4 more
core   +1 more source

Immunofluorescence stimulated emission depletion microscopy

Nature Biotechnology, 2003
We report immunofluorescence imaging with a spatial resolution well beyond the diffraction limit. An axial resolution of approximately 50 nm, corresponding to 1/16 of the irradiation wavelength of 793 nm, is achieved by stimulated emission depletion through opposing lenses. We have demonstrated not only that an antibody-tagged label is stable enough to
Dyba, Marcus, Jakobs, Stefan, Hell, Stefan   +2 more
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Técnica de bombeio e prova para medidas de absorção de estado excitado e de emissão estimulada, em materiais sólidos dopados com íons terras raras Pump-probe technique for excited state absorption and stimulated emission measurements in rare earth ion doped solid materials

Química Nova, 2008
Rare earth ion doped solid state materials are the most important active media of near-infrared and visible lasers and other photonic devices. In these ions, the occurrence of Excited State Absorptions (ESA), from long lived electronic levels, is ...
Andrea Simone Stucchi de Camargo, Luiz Antonio de Oliveira Nunes   +1 more
doaj   +1 more source

Lambda's, V's and optimal cloning with stimulated emission

, 2000
We show that optimal universal cloning of the polarization state of photons can be achieved via stimulated emission in three-level systems, both of the Lambda and the V type.
C. Simon, D. Bruss, D. Dieks, E. Hagley, G. Weihs, J. J. Sakurai, J. Kempe, N. Gisin, N. Gisin, N. Herbert, R. F. Werner, V. Bužek, W. K. Wootters   +12 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Photoacoustic detection of stimulated emission pumping in p-difluorobenzene [PDF]

, 1984
Photoacoustic detection has been used to monitor a stimulated emission pumping process in p‐difluorobenzene. Using the Ã^(1)B_(2u)5^1 state as an intermediate, several vibrational levels of the ground electronic state were populated.
Kuppermann, A., Moll, D. J., Parker, G. R., Jr.   +2 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source