Results 41 to 50 of about 233,089 (385)

STING trafficking as a new dimension of immune signaling

Journal of Experimental Medicine, 2023
STING signaling is at the center of multiple autoinflammatory and neurodegenerative diseases. The authors review how STING trafficking influences signaling, propose a model of tonic STING signaling, and discuss an emerging link between dysregulated STING
Devon Jeltema, Kennady Abbott, Nan Yan
semanticscholar   +1 more source

The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression

OncoImmunology, 2017
Regressing tumors are usually associated with a large immune infiltrate, but the molecular and cellular interactions that govern a successful anti-tumor immunity remain elusive.
Julia M. Weiss, Marion V. Guérin, Fabienne Regnier, Gilles Renault, Isabelle Galy-Fauroux, Lene Vimeux, Vincent Feuillet, Elisa Peranzoni, Maxime Thoreau, Alain Trautmann, Nadège Bercovici   +10 more
doaj   +1 more source

Mn-based cGAS-STING activation for tumor therapy.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2023
Immunotherapy has efficiently revolutionized the treatment of human neoplastic diseases. However, the overall responsive rate of current immunotherapy is still unsatisfactory, benefiting only a small proportion of patients.
Aiping Huang, Wenhao Zhou
semanticscholar   +1 more source

The Sting of the Bee [PDF]

Nature, 1879
IN “The Origin of Species,” p. 242, fourth edition, Mr. Darwin says, “If we look at the sting of the bee as having originally existed in a remote progenitor as a boring and serrated instrument, like that in so many members of the same great order, and which has been modified, but not perfected, for its present purpose, with the poison, originally ...
openaire   +3 more sources

Stinging and Rosacea

Acta Dermato-Venereologica, 1999
A total of 32 rosacea patients (25 with the papulopustular type of rosacea and 7 with the erythematotelangiectatic type) and 32 healthy persons were single-blind tested with a solution of 5% lactic acid and pure water applied to their cheeks.
Sol-Britt Lonne-Rahm, Mats Berg, Fischer T   +2 more
openaire   +3 more sources

Regulating STING in health and disease. [PDF]

, 2017
The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named "STimulator of INterferon Genes (STING)".
A Ablasser, A Fiszer-Kierzkowska, A Nazmi, A Takaoka, AC Collins, AG York, AH Rahman, AJ Sadler, AJ Schmidt, AK Lakkaraju, AN Harman, AP West, B Vries de, B Zhong, B Zhong, BA Diner, BW Davies, C Castanier, C Enevold, C Flück, C Günther, C Kooten van, C Shu, C Wolf, CHA Tang, CK Holm, CK Holm, CK Holm, D Bansal, D Cuchet-Lourenco, D Gao, D Gao, D Zhu, DH Barouch, DH Nguyen, DJ Gough, DJ Wallace, DL Burdette, DW Hommes, E Lam, E Lee, E Meylan, EE Gray, EG Boyce, EJ Diner, EN Benveniste, Endre Kiss-Toth, F Martínez Valle, G Surpris, G Trinchieri, G Uzé, GI Rice, GI Rice, GJ Seo, GN Barber, H Chen, H Chen, H Guo, H Ishikawa, H Ishikawa, H Ishikawa, H Miyabe, H Oda, Heather L. Wilson, HHL Borba, I Kamga, J Ahn, J Diamond, J Fu, J Goverman, J Klarquist, J Langhorne, J Lippmann, J Wu, J Wu, JC Ravenscroft, JD Sauer, JE Hagstrom, JE Vance, JJ Woodward, JJ Wu, JM Tran Janco, JT Merrill, JW Schoggins, K Eguchi, K Maringer, K Miyamoto, K Nagasawa, K Saukkonen, KG Lee, KJ Mackenzie, KY Su, L Corrales, L Deng, L Ding, L Jin, L Jin, L Jin, L Jin, L Lau, L Li, L Sun, L Unterholzner, L Zhang, L-G Xu, LAJ O’Neill, LB Ivashkiv, M Blanc, M Chawla-Sarkar, M Christen, M Kalamvoki, M Lolicato, M Zheng, M-L Frémond, MC Gauzzi, MH Christensen, MH Christensen, MJ Veer de, MK Atianand, MK Crow, ML Yarbrough, MP Rodero, MR Arbuckle, MR Jakobsen, MR Thompson, MS Diamond, N Au-Yeung, N Gratz, N Jeremiah, N Kerur, N Ranganath, N Yan, NF Moore, P Gao, P Gao, Q Liang, Q Wang, Q Yin, R Furie, R Salloum, RB Seth, RO Watson, RO Watson, S Barman, S Liu, S Marchi, S Nitta, S Ouyang, S Sharma, SB Rasmussen, SR Woo, SR Woo, T Abe, T Abe, T Doyle, T Kawai, T Li, T Nakamura, T Tsuchida, TB Niewold, TM Allen, U Koppe, U Ravnskov, V Dell’Oste, V Hornung, V Pokatayev, VP Torchilin, VR DeFilippis, W Sun, W Zhang, WM Schneider, X Lahaye, X Li, X Yu, X Zhang, Y Bai, Y Kai Chan, Y Liu, Y Liu, Y Tanaka, Y-H Huang, Yang Li, YH Chiu, YJ Crow, Z Liao, Z Ma, Z Zhang, Z Zhang   +187 more
core   +2 more sources

STING an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signaling

Nature, 2008
The cellular innate immune system is essential for recognizing pathogen infection and for establishing effective host defence. But critical molecular determinants responsible for facilitating an appropriate immune response—following infection with DNA ...
Hiroki Ishikawa, G. Barber
semanticscholar   +1 more source

STING Millennium: a web-based suite of programs for comprehensive and simultaneous analysis of protein structure and sequence. [PDF]

, 2019
Sting Millennium suite intrinsics. SMS organization. Sting Millennium Modes. Sting Millennium Modules. Millennium Features.
ALMEIDA, C. L. de, BAUDET, C., CAMPOS, T. F. e, COSTA, I. C., DOMINIQUINI, F., FALCAO, P. R. K., FERREIRA, L. L., FREITAS, E. M. de, GOMES, G. B., HIGA, R. H., HORITA, L. G., INOUE, M. K., LIMA, C. S., LUNA, F. M., MANCINI, A. L., MATTIUZ, A. R., MIURA, R. T., NESHICH, G., OGAWA, F. O., OLIVEIRA, A. G., PALANDRANI, J. F., PAPPAS JUNIOR, G., SANTOS, G. F. dos, SOUZA, D. F. de, SOUZA, S., TOGAWA, R. C., TORRES, W. V., YAMAGISHI, M. E. B., ÁLVARO, A.   +28 more
core   +1 more source

The Sting's the Thing

CHIMIA, 2019
Bees defend themselves by stinging and injecting a venom into their victims; bee venom is a complex mixture of chemicals including the polypeptide melittin which is mainly responsible for triggering the pain of the sting.
openaire   +7 more sources

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear.
Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie Cordonnier, M. Mattson, D. Croteau, V. Bohr   +8 more
semanticscholar   +1 more source