Results 51 to 60 of about 53,540 (290)
Arthritis Care &Research, EarlyView.Objective This study aimed to identify themes contributing to resilience in childhood‐onset systemic lupus erythematosus (cSLE), distinguish between profiles of resilience, and examine how they relate to underlying themes and patient characteristics. Methods We conducted a mixed‐methods study of 21 patients with cSLE aged 11 to 19 years at a Canadian ...
Isabella Zaffino +12 more
wiley +1 more source
A quantitative method to monitor STING degradation with dual-luciferase reporters
Cell Structure and FunctionStimulator of interferon genes (STING) triggers the type I interferon and inflammatory responses against a variety of DNA pathogens, which is essential to limiting viral infection and replication.
Tsumugi Shoji +8 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2018 Stimulator of interferon genes (STING) was defined as an important molecule for promoting antitumor immunity through mediating type I interferon (IFN) production by sensing its ligands such as cyclic GMP-AMP (cGAMP).
Takayuki Ohkuri +3 more
doaj +1 more source
The sting is in the tale [PDF]
Current Biology, 2006 Research is driven as much by new technology as by new ideas. Just think of the way biology has changed out of all recognition during the last 35 years as a result of, amongst other things, DNA cloning, Southern blotting, microarrays, mass spectroscopy, and high throughput DNA sequencing.
openaire +2 more sources
Arthritis Care &Research, Accepted Article.Objectives Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centred care and informing local service pathways and care guidelines or standards.
Sonia Ranelli +8 more
wiley +1 more source
cGAS-independent STING activation in response to DNA damage
Molecular & Cellular Oncology, 2019 Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the ...
Leonie Unterholzner, Gillian Dunphy
doaj +1 more source
Mitochondrial control of innate immune signaling by irradiated cancer cells
OncoImmunology, 2020 Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of ...
Takahiro Yamazaki, Lorenzo Galluzzi
doaj +1 more source
Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β
Advanced Biology, EarlyView.This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer +8 more
wiley +1 more source
LIN28B Promotes Cancer Cell Dissemination and Angiogenesis
Advanced Biology, EarlyView.Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo +8 more
wiley +1 more source
Human-Wildlife Interactions, 2017 This paper presents information on emergency department (ED) visits and hospitalizations resulting from an animal-caused injury from 2006 to 2008 using data collected from the Agency for Healthcare Research and Quality.
Ricky L. Langley
doaj +1 more source