Results 51 to 60 of about 233,089 (385)

Idealised simulations of sting-jet cyclones [PDF]

, 2014
An idealised modelling study of sting-jet cyclones is presented. Sting jets are descending mesoscale jets that occur in some extratropical cyclones and produce localised regions of strong low-level winds in the frontal fracture region.
Baker, Balasubramanian, Beare, Bennetts, Bjerknes, Boutle, Browning, Browning, Browning, Cao, Clark, Davies, Durran, Edwards, Emanuel, Emanuel, Gray, Gray, Gregory, Lock, Martínez-Alvarado, Martínez-Alvarado, Martínez-Alvarado, Novak, Parton, Parton, Persson, Polvani, Schultz, Shapiro, Shapiro, Tan, Thorncroft, Weisman, Wernli, Whitaker, Wilson   +36 more
core   +1 more source

cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation

Cell communication and signaling : CCS
Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and pyroptosis act as critical natural immune signaling axes for microbial infection, chronic inflammation, cancer progression and organ degeneration, but the mechanism and regulation
Jingwen Liu, Jing Zhou, Yuling Luan, Xiaoying Li, Xiangrui Meng, Wenhao Liao, Jianyuan Tang, Zheilei Wang   +7 more
semanticscholar   +1 more source

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The cGAS-STING pathway is important for immune defense against infection and cancer. STING activation triggers multiple signaling cascades leading to activation of IRF3, NF-κB, and autophagy.
S. Yum, Minghao Li, Yan Fang, Zhijian J. Chen   +3 more
semanticscholar   +1 more source

LONG STINGS [PDF]

The Canadian Entomologist, 1882
In the May number of the Canadian Entomologist there is a very interesting paper under this caption, contributed by Mr. Harrington, giving an account of the habits of the Rhyssa atrata and lunator. These Long Stings the past summer were very abundant at Oak Hill, the residence of Mr. Herman T.
openaire   +2 more sources

STING licensing of type I dendritic cells potentiates antitumor immunity

Science immunology
Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP in response to self or microbial cytosolic DNA as a danger signal.
Jian Wang, Suxin Li, Maggie Wang, Xu Wang, Shuqing Chen, Zhichen Sun, Xiubao Ren, Gang Huang, B. Sumer, Nan Yan, Yang-Xin Fu, Jinming Gao   +11 more
semanticscholar   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Mitochondrial control of innate immune signaling by irradiated cancer cells

OncoImmunology, 2020
Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of ...
Takahiro Yamazaki, Lorenzo Galluzzi
doaj   +1 more source

STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer

Cell Stress, 2023
Adoptive cell therapy (ACT) can successfully treat hema-topoietic cancers but lacks efficacy against solid tumors. This is due to insufficient T cell infiltration, high tumor heterogeneity, frequent antigen loss with subsequent tumor escape, and the ...
Fabian Richter, Christophe Paget, Lionel Apetoh   +2 more
doaj   +1 more source

STING contributes to lipopolysaccharide-induced tubular cell inflammation and pyroptosis by activating endoplasmic reticulum stress in acute kidney injury

Cell Death and Disease
Recently, innate immunity and inflammation were recognized as the key factors for acute kidney injury (AKI) caused by sepsis, which is closely related to high mortality. Stimulator of interferon genes (STING) has emerged as a critical component of innate
Yun Cao, Xinghua Chen, Zijing Zhu, Zilv Luo, Yiqun Hao, Xueyan Yang, Jun Feng, Zongwei Zhang, Jijia Hu, Yonghong Jian, Jiefu Zhu, Wei Liang, Zhaowei Chen   +12 more
semanticscholar   +1 more source

BEES' STINGS AND RHEUMATISM [PDF]

BMJ, 1907
IT appears to be a familiar and widespread belief in many countries that the stings of bees act both protectively and as a cure for “rheumatism.” I have recently been able to collect some definite evidence in support of the belief in question.
openaire   +8 more sources