Results 121 to 130 of about 30,783 (304)
Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia
Interdisciplinary Medicine, EarlyView.For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang +13 more
wiley +1 more source
Comparative Population Studies, 2012 Stochastic population forecasts are gaining popularity in these times of demographic change, as compared with the scenario technique frequently used for projections, they provide important additional information: the forecasted population lies within a ...
Philipp Deschermeier
doaj
Guaranteed Annuity Option Under Correlated and Regime-Switching Risks
RisksGuaranteed annuity options (GAOs) allow policyholders to convert accumulated funds into life annuities at maturity at a guaranteed minimum rate. Thus, insurers are exposed to both investment and longevity risks.
Jude Martin B. Grozen, Rogemar S. Mamon
doaj +1 more source
Life is Cheap: Using Mortality Bonds to Hedge Aggregate Mortality Risk [PDF]
Using the widely-cited Lee-Carter mortality model, we quantify aggregate mortality risk as the risk that the average annuitant lives longer than is predicted by the model, and we conclude that annuity business exposes insurance companies to substantial ...
Leora Friedberg, Anthony Webb
core
Bayesian Model Averaging in Causal Instrumental Variable Models
Journal of Applied Econometrics, EarlyView.ABSTRACT Instrumental variables are a popular tool to infer causal effects under unobserved confounding, but choosing suitable instruments is challenging in practice. We propose gIVBMA, a Bayesian model averaging procedure that addresses this challenge by averaging across different sets of instrumental variables and covariates in a structural equation ...
Gregor Steiner, Mark Steel
wiley +1 more source
Modeling Mortality: Empirical Studies on the Effect of Mortality on Annuity Markets.
Chapter 3 of the dissertation models the macro-longevity risk and introduces a stochastic model for human mortality rates. Chapter 4 analyzes the importance of mortality improvement and mortality risk (macro- and micro-longevity risk and parameter ...
Hari, N.
core
Debilitation's Aftermath: Stochastic Process Models of Mortality
, 1986 The paper is devoted to the analysis of stochastic process models of mortality which can explain both selection and debilitation processes in the evolution of cohort mortality. The relative importance of each process is analyzed.
Vaupel, J.W., Manton, K.G., Yashin, A.I.
core
Mathematical Methods in the Applied Sciences, EarlyView.ABSTRACT We investigate some chemostat models incorporating wall growth, competition, random fluctuations on the dilution rate, and different consumption functions (Monod and Haldane). We analyze the asymptotic behavior of the solutions of the corresponding random differential systems to establish conditions on the model parameters under which the ...
Javier López‐de‐la‐Cruz +2 more
wiley +1 more source
Frontiers in Cardiovascular MedicineIntroductionAccurate in-hospital mortality prediction following percutaneous coronary intervention (PCI) is crucial for clinical decision-making. Machine Learning (ML) and Data Mining methods have shown promise in improving medical prognosis accuracy ...
Nan Tang +8 more
doaj +1 more source