Results 141 to 150 of about 931,046 (255)

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

open access: yesThe FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

A novel nonlinear PID controller design with adaptive gains. [PDF]

open access: yesSci Rep
Ozgun AS   +3 more
europepmc   +1 more source

Uniformly Ultimate Boundedness Control for Uncertain Switched Linear Systems

open access: yes, 2003
In this paper, piecewise linear switched systems affected by both parameter variations and exterior disturbances are considered. The problem of synthesis of switching laws, which assure that the system state is ultimately bounded within a given compact ...
Panos J. Antsaklis, Hai Lin
core  

Dispersal mediates metapopulation response to local and regional stressors

open access: yesInsect Conservation and Diversity, EarlyView.
A feature of recent insect declines is that widespread, formerly common species are among the worst affected. We designed a metapopulation simulation to ask how dispersal capability interacts with landscape and population stressors that act at different spatial scales.
Christopher A. Halsch   +2 more
wiley   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

open access: yesImmunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos   +5 more
wiley   +1 more source

Linking the Comparison and Graphical Approaches to Bipartite Matching

open access: yesInternational Statistical Review, EarlyView.
Summary Bipartite record linkage has the goal of identifying observations referring to the same individual, called coreferent observations, across two distinct non‐duplicated datasets. The two main approaches to solve this task are the Fellegi–Sunter model, which relies on pairwise comparisons of observations, and the graphical record linkage model ...
Edoardo Redivo
wiley   +1 more source

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