Results 71 to 80 of about 17,092 (308)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Effects of Tilapia Stocking Densities on Fish Growth and Water Quality in Tanks

Asian Fisheries Science, 2000
The effects of feed input and stocking density (1, 5, 10 and 15 kg.m-3 ) of hybrid tilapia (Oreochromis niloticus x O. aureus) on growth and water quality were investigated.
A.H. AL-HARBI, A.Q. SIDDIQUI
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Growth performance of the sea cucumber Holothuria scabra and the seaweed Eucheuma denticulatum: integrated mariculture and effects on sediment organic characteristics

Aquaculture Environment Interactions, 2016
Deposit-feeding sea cucumbers play a key role in marine ecosystems through bioturbation, burrowing and feeding on organic matter in marine sediments.
M Namukose, FE Msuya, SCA Ferse, MJ Slater, A Kunzmann   +4 more
doaj   +1 more source

Growth, yield and economic returns of striped catfish (Pangasianodon hypophthalmus) at different stocking densities under floodplain cage culture system

Egyptian Journal of Aquatic Research, 2020
The influence of stocking density plays one of the major roles in the final production for profitable aquaculture. This study was conducted to investigate the effect of stocking density on growth, yield and economic return of striped catfish ...
Md. Atick Chowdhury, Nirmal Chandra Roy, Angkur Chowdhury   +2 more
doaj   +1 more source

Growth performance and physiological responses of helmeted guinea fowl (Numida meleagris) to different stocking densities in humid tropical environment [PDF]

, 2020
O.E. Oke, A. O. Oso, O.S. Iyasere, Tolulope Adebowale, Tolulope Akanji, Odutola Odusami, Sandra Udehi, J. O. Daramola   +7 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effect of stocking density on growth and yield of Labeo bata fingerlings reared in cages

Aquaculture Reports, 2020
An experiment was carried out to evaluate the growth performance and yield of Labeo bata reared in cages at different stocking densities in a floodplain wetland of Assam, India.
Sona Yengkokpam, Basanta Kumar Das, Dipesh Debnath, Pronob Das, Anil Kumar Yadav, Niti Sharma, Simanku Borah, Ningthoujam Samarendra Singh, Kishore Kumar Sarma, Bipul Chandra Ray, Amulya Kakati, Birendra Kumar Bhattacharjya   +11 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source