Results 191 to 200 of about 159,363 (373)

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino   +21 more
wiley   +1 more source

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou   +17 more
wiley   +1 more source

Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Enrichment of sphingomyelin in the HIV‐1 envelope arises from Gag binding to PI(4,5)P2, which triggers reorganization of plasma membrane sphingomyelin/cholesterol domains through unknown mechanisms. We propose that cholesterol‐mediated interleaflet coupling between sphingomyelin and PI(4,5)P2, rather than interdigitation, underlies Gag‐induced lipid ...
Nario Tomishige   +2 more
wiley   +1 more source

Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas

open access: yesChemMedChem, Volume 21, Issue 1, January 2026.
Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci   +6 more
wiley   +1 more source

Editorial: Methods in experimental pharmacology 2023

open access: yesFrontiers in Pharmacology
Somasundaram Arumugam   +2 more
doaj   +1 more source

Effects of glycyrrhizin on healing and prevention of recurrent aphthous stomatitis in hamster models. [PDF]

open access: yesPLoS One
Shiba F   +6 more
europepmc   +1 more source

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