Results 81 to 90 of about 514,667 (286)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Release the BEESTS: Bayesian Estimation of Ex-Gaussian STop-Signal Reaction Time Distributions

Frontiers in Psychology, 2013
The stop-signal paradigm is frequently used to study response inhibition. Inthis paradigm, participants perform a two-choice response time task wherethe primary task is occasionally interrupted by a stop-signal that promptsparticipants to withhold their ...
Dora eMatzke, Jonathon eLove, Thomas V Wiecki, Scott D Brown, Gordon D Logan, Eric-Jan eWagenmakers   +5 more
doaj   +1 more source

Hierarchical Bayesian analysis reveals complex neural dynamics of inhibitory control [PDF]

, 2018
Cognitive control has been of interest to psychologists and neuroscientists because of its contribution to understanding individual differences, impulsivity, addiction, and obsessive-compulsive disorder.
Molloy, M. Fiona
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Event-related potentials for post-error and post-conflict slowing. [PDF]

PLoS ONE, 2014
In a reaction time task, people typically slow down following an error or conflict, each called post-error slowing (PES) and post-conflict slowing (PCS). Despite many studies of the cognitive mechanisms, the neural responses of PES and PCS continue to be
Andrew Chang, Chien-Chung Chen, Hsin-Hung Li, Chiang-Shan R Li   +3 more
doaj   +1 more source

Cognitive Function of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder in a 2-Year Open-Label Study of Lisdexamfetamine Dimesylate [PDF]

, 2018
BACKGROUND: SPD489-404 was the first 2-year safety study of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in children and adolescents.
Alessandro Zuddas, American Psychiatric Association, BJ Sahakian, Brigitte Robertson, Caleb Bliss, CY Shang, D Coghill, D Coghill, David R. Coghill, DR Coghill, DR Coghill, DR Coghill, DR Coghill, DR Coghill, DR Coghill, DR Coghill, FC Soares, GJ DuPaul, H Kovshoff, J Biederman, J Lipszyc, JE Grant, K Wild, LA Adler, P Jakala, R Fried, R Weisler, RL Findling, RL Findling, RM Bilder, RW Dittmann, SM Rhodes, SR Chamberlain, SS Gau, Tobias Banaschewski, TW Robbins   +35 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

On the interplay between state-dependent reconfigurations of global signal correlation and BOLD fluctuations: An fMRI study

NeuroImage
Background: The dynamics of global, state-dependent reconfigurations in brain connectivity are yet unclear. We aimed at assessing reconfigurations of the global signal correlation coefficient (GSCORR), a measure of the connectivity between each voxel ...
Stefano Damiani, Paolo La-Torraca-Vittori, Livio Tarchi, Eleonora Tosi, Valdo Ricca, Andrea Scalabrini, Pierluigi Politi, Paolo Fusar-Poli   +7 more
doaj   +1 more source

The impact of yohimbine-induced arousal on facets of behavioural impulsivity [PDF]

, 2012
Rationale State-dependent changes in physiological arousal may influence impulsive behaviours. Objectives To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α2-adrenergic receptor antagonist, which ...
Herman, Aleksandra M, Critchley, Hugo D, Duka, Theodora   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source