Results 11 to 20 of about 270,897 (278)

Translational termination without a stop codon [PDF]

Science, 2016
Rescuing stalled ribosomes A small percentage of bacterial mRNAs lack a stop codon. Ribosomes stall at the end of such mRNAs, and the buildup of stalled ribosomes can be lethal. The primary rescue mechanism, in which translation continues on a piece of RNA that contains a stop codon, is a drug target.
Nathan R, James, Alan, Brown, Yuliya, Gordiyenko, V, Ramakrishnan   +3 more
openaire   +4 more sources

Structural basis for stop codon recognition in eukaryotes [PDF]

Nature, 2015
Termination of protein synthesis occurs when a translating ribosome encounters one of three universally conserved stop codons: UAA, UAG or UGA. Release factors recognize stop codons in the ribosomal A-site to mediate release of the nascent chain and recycling of the ribosome. Bacteria decode stop codons using two separate release factors with differing
Alan, Brown, Sichen, Shao, Jason, Murray, Ramanujan S, Hegde, V, Ramakrishnan   +4 more
openaire   +4 more sources

The Stop Codon after the nsp3 Gene of Ross River Virus (RRV) Is Not Essential for Virus Replication in Three Cell Lines Tested, but RRV Replication Is Attenuated in HEK 293T Cells [PDF]

Viruses
A recombinant Ross River virus (RRV) that contains the fluorescent protein mCherry fused to the non-structural protein 3 (nsP3) was constructed, which allowed real-time imaging of viral replication.
Christin Schmidt, Julia Gerbeth, Christine von Rhein, Florian D. Hastert, Barbara S. Schnierle   +4 more
doaj   +2 more sources

The complete mitochondrial genome of Abramites hypselonotus (Günther, 1868) (Ostariophysi: Characiformes: Anostomidae): an aquarium headstander

Mitochondrial DNA. Part B. Resources, 2021
Abramites hypselonotus, commonly known as marbled headstander, is an important freshwater aquarium fish from Brazil, found in the Orinoco, Amazon, Paraguay and lower Parana River basins.
Adma Kátia Lacerda-Chaves, Adriana Heloísa Pereira, Evanguedes Kalapothakis   +2 more
doaj   +1 more source

Engineering a genomically recoded organism with one stop codon. [PDF]

Nature
Grome MW, Nguyen MTA, Moonan DW, Mohler K, Gurara K, Wang S, Hemez C, Stenton BJ, Cao Y, Radford F, Kornaj M, Patel J, Prome M, Rogulina S, Sozanski D, Tordoff J, Rinehart J, Isaacs FJ.   +17 more
europepmc   +2 more sources

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae.

PLoS Genetics, 2021
Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release.
Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard Baker, Allan Jacobson   +5 more
doaj   +1 more source

First determination and analysis of the complete mitochondrial genome of X-ray tetra Pristella maxillaris (Ulrey, 1894) (Actinopteri, Characidae)

Mitochondrial DNA. Part B. Resources, 2022
The complete mitochondrial genome of the X-ray tetra (Pristella maxillaris, Ulrey, 1894) was determined by using next-generation sequencing technology, and its mitochondrial genome characteristics were analyzed.
Chuangbin Tang, Lijuan Wei, Qiuchan Huang, Qihai Zhou, Guohai Wang   +4 more
doaj   +1 more source

T-G-A Deficiency Pattern in Protein-Coding Genes and Its Potential Reason

Frontiers in Microbiology, 2022
If a stop codon appears within one gene, then its translation will be terminated earlier than expected. False folding of premature protein will be adverse to the host; hence, all functional genes would tend to avoid the intragenic stop codons. Therefore,
Yan-Ting Jin, Yan-Ting Jin, Dong-Kai Pu, Hai-Xia Guo, Zixin Deng, Ling-Ling Chen, Feng-Biao Guo   +6 more
doaj   +1 more source

Regulation of A-to-I RNA editing and stop codon recoding to control selenoprotein expression during skeletal myogenesis

Nature Communications, 2022
Stop codon recoding is a unique mechanism for selenoprotein biogenesis. Here, the authors report regulatory systems for selenoprotein expression during skeletal muscle differentiation by regulating A-to-I RNA editing and stop codon recoding.
Yuta Noda, Shunpei Okada, Tsutomu Suzuki
doaj   +1 more source

Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release. [PDF]

, 2018
Termination of protein synthesis is triggered by the recognition of a stop codon at the ribosomal A site and is mediated by class I release factors (RFs).
Clementi, Nina, Erlacher, Matthias David, Faserl, Klaus, Gasser, Catherina, Hoernes, Thomas Philipp, Hüttenhofer, Alexander, Joseph, Simpson, Juen, Michael Andreas, Kreutz, Christoph, Lindner, Herbert, Shi, Xinying, Willi, Jessica   +11 more
core   +3 more sources