Results 61 to 70 of about 270,897 (278)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The mitochondrial genome of Syneches medoganus (Diptera: Empididae)
Mitochondrial DNA. Part B. Resources, 2021 The mitogenome of one dance fly species, Syneches medoganus, was sequenced as the new representative of subfamily Hybotinae. The nearly complete mitogenome was 16128 bp totally, consisting of 13 protein-coding genes (PCGs), two rRNA genes, and 22 tRNA ...
Wei Zeng, Yan Gu, Ding Yang
doaj +1 more source
Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]
, 2014 Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Croft, Wayne D. +4 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The fail-safe system to rescue the stalled ribosomes in Escherichia coli
Frontiers in Microbiology, 2014 Translation terminates at stop codon. Without stop codon, ribosome cannot terminate translation properly and reaches and stalls at the 3' end of the mRNA lacking stop codon.
Tatsuhiko eAbo, Yuhei eChadani
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
PLoS ONE, 2015 BackgroundThe genetic background of Growth Hormone (GH) secretion is not well understood. Mutations giving rise to a stop codon have a high likelihood of affecting protein function.ObjectivesTo analyze likely functional stop codon mutations that are ...
Erik Hallengren +4 more
doaj +1 more source
Complete mitochondrial genome of Plodia interpunctella (Lepidoptera: Pyralidae)
Mitochondrial DNA. Part B. Resources, 2020 The Plodia interpunctella belongs to Pyralidae in Lepidoptera. The complete mitogenome of P. interpunctella was described in this study, which is typically circular duplex molecules and 15,403 bp in length, containing the standard metazoan set of 13 ...
Yu-Peng Wu, Tian-Juan Su, Bo He
doaj +1 more source
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]
, 2019 This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A. +6 more
core +1 more source
Computational analysis of stop codon readthrough in D.melanogaster [PDF]
Bioinformatics, 2003 Abstract Motivation: Readthrough is an unusual process in which a stop codon is misread or skipped. Recently it has been shown that some translation is regulated by the readthrough reactions although the complete mechanism is not clear.
Misaki, Sato +4 more
openaire +2 more sources