Results 121 to 130 of about 7,802 (179)

Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP. [PDF]

Nucleic Acids Res, 2023
Lyu Z, Villanueva P, O'Malley L, Murphy P, Augenstreich J, Briken V, Singh A, Ling J.   +7 more
europepmc   +1 more source

Cysteine tRNA acts as a stop codon readthrough-inducing tRNA in the human HEK293T cell line. [PDF]

RNA, 2023
Valášek LS, Kučerová M, Zeman J, Beznosková P.   +3 more
europepmc   +1 more source

Inhibition of Nonsense-Mediated mRNA Decay by Antisense Morpholino Oligonucleotides Restores Functional Expression of hERG Nonsense and Frameshift Mutations in Long-QT Syndrome

, 2010
Mutations in the human ether-a-go-go-related gene (hERG) cause long-QT syndrome type 2 (LQT2). We previously described a homozygous LQT2 nonsense mutation Q1070X in which the mutant mRNA is degraded by nonsense-mediated mRNA decay (NMD) leading to a ...
Bhuiyan, Bhuiyan, Conti, Curran, Dominski, Friedman, Frischmeyer, Gong, Gong, Gritz, Holbrook, Howard, Jearawiriyapaisarn, Kapplinger, Khajavi, Kuzmiak, Le Hir, Le Roy, Linde, Lykke-Andersen, Matthew R. Stump, Millat, Nagy, Napolitano, Nicholson, Qiuming Gong, Sanguinetti, Schwartz, Shimizu, Splawski, Stalder, Tester, Trudeau, Usuki, Wu, Yao, Zhang, Zhengfeng Zhou, Zhou, Zhou   +39 more
core   +1 more source

Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations

Frontiers in Pharmacology
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Premature termination codons (PTCs) represent ∼9% of CF mutations that typically cause severe expression defects of the CFTR anion ...
Aiswarya Premchandar, Ruiji Ming, Abed Baiad, Dillon F. Da Fonte, Haijin Xu, Denis Faubert, Guido Veit, Gergely L. Lukacs, Gergely L. Lukacs   +8 more
doaj   +1 more source

Identification and functional characterization of mRNAs that exhibit stop codon readthrough in Arabidopsis thaliana. [PDF]

J Biol Chem, 2022
Sahoo S, Singh D, Singh A, Pandit M, Vasu K, Som S, Pullagurla NJ, Laha D, Eswarappa SM.   +8 more
europepmc   +1 more source

The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection

Viruses
The interferon-induced host cell protein Shiftless (SFL) inhibits −1 programmed ribosomal frameshifting (−1PRF) required for the expression of HIV-1 Gal-Pol and the formation of infectious HIV-1 particles.
Niklas Jäger, Shreya Ahana Ayyub, Frank Peske, David Liedtke, Jens Bohne, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann   +7 more
doaj   +1 more source

Relocalization of Translation Termination and Ribosome Recycling Factors to Stress Granules Coincides with Elevated Stop-Codon Readthrough and Reinitiation Rates upon Oxidative Stress. [PDF]

Cells, 2023
Makeeva DS, Riggs CL, Burakov AV, Ivanov PA, Kushchenko AS, Bykov DA, Popenko VI, Prassolov VS, Ivanov PV, Dmitriev SE.   +9 more
europepmc   +1 more source

Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development. [PDF]

BMC Biol, 2021
Zhao Y, Lindberg BG, Esfahani SS, Tang X, Piazza S, Engström Y.   +5 more
europepmc   +1 more source

Anotación del genoma humano y de ratón [PDF]

, 2018
Trabajo fin de máster en Bioinformática y Biología ComputacionalA pesar de que han pasado más de diez años de la publicación de la secuencia del genoma humano, sigue sin esclarecerse un número final de genes codificantes. Para el estudio y comprensión de
Martínez Gómez, Laura
core   +1 more source

Modulation of Viral Programmed Ribosomal Frameshifting and Stop Codon Readthrough by the Host Restriction Factor Shiftless. [PDF]

Viruses, 2021
Napthine S, Hill CH, Nugent HCM, Brierley I.   +3 more
europepmc   +1 more source